Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67.

Thirty-one cervical biopsies of invasive carcinoma have been studied by immunohistochemical means using the monoclonal antibody Ki67 to determine tumour cell proliferation rates. A wide range (10-50%) in the extent of Ki67 staining (expressed as the percentage of labelled tumour cells) was observed...

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Autores principales: Brown, D. C., Cole, D., Gatter, K. C., Mason, D. Y.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246434/
https://www.ncbi.nlm.nih.gov/pubmed/3282535
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author Brown, D. C.
Cole, D.
Gatter, K. C.
Mason, D. Y.
author_facet Brown, D. C.
Cole, D.
Gatter, K. C.
Mason, D. Y.
author_sort Brown, D. C.
collection PubMed
description Thirty-one cervical biopsies of invasive carcinoma have been studied by immunohistochemical means using the monoclonal antibody Ki67 to determine tumour cell proliferation rates. A wide range (10-50%) in the extent of Ki67 staining (expressed as the percentage of labelled tumour cells) was observed indicating considerable variation on tumour growth rates. There was no significant relationship between the percentage of positive cells and conventional histological parameters such as cell type or tumour differentiation. Immunostaining with monoclonal antibody Ki67 therefore provides a new approach to the assessment of cervical tumour biopsies which will require long term clinical follow-up to establish its prognostic significance. IMAGES:
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spelling pubmed-22464342009-09-10 Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67. Brown, D. C. Cole, D. Gatter, K. C. Mason, D. Y. Br J Cancer Research Article Thirty-one cervical biopsies of invasive carcinoma have been studied by immunohistochemical means using the monoclonal antibody Ki67 to determine tumour cell proliferation rates. A wide range (10-50%) in the extent of Ki67 staining (expressed as the percentage of labelled tumour cells) was observed indicating considerable variation on tumour growth rates. There was no significant relationship between the percentage of positive cells and conventional histological parameters such as cell type or tumour differentiation. Immunostaining with monoclonal antibody Ki67 therefore provides a new approach to the assessment of cervical tumour biopsies which will require long term clinical follow-up to establish its prognostic significance. IMAGES: Nature Publishing Group 1988-02 /pmc/articles/PMC2246434/ /pubmed/3282535 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Brown, D. C.
Cole, D.
Gatter, K. C.
Mason, D. Y.
Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67.
title Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67.
title_full Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67.
title_fullStr Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67.
title_full_unstemmed Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67.
title_short Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67.
title_sort carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody ki67.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246434/
https://www.ncbi.nlm.nih.gov/pubmed/3282535
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