Macrophages in human breast disease: a quantitative immunohistochemical study.

We describe a quantitative histological study of 34 breast biopsies using a marker for human macrophages, the monoclonal antibody EBM/11. Seventeen of the biopsies were of malignant tumours. Both benign and malignant breast tissue contained large numbers of macrophages with significantly higher numb...

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Autores principales: Kelly, P. M., Davison, R. S., Bliss, E., McGee, J. O.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246436/
https://www.ncbi.nlm.nih.gov/pubmed/2833921
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author Kelly, P. M.
Davison, R. S.
Bliss, E.
McGee, J. O.
author_facet Kelly, P. M.
Davison, R. S.
Bliss, E.
McGee, J. O.
author_sort Kelly, P. M.
collection PubMed
description We describe a quantitative histological study of 34 breast biopsies using a marker for human macrophages, the monoclonal antibody EBM/11. Seventeen of the biopsies were of malignant tumours. Both benign and malignant breast tissue contained large numbers of macrophages with significantly higher numbers occurring in the malignant group. An analysis was made of macrophage counts according to stage, grade and prognostic index of the malignant tumours. There was no correlation between macrophage numbers and any of these parameters in malignant breast tumours. We discuss the possible reasons why some earlier studies (using other markers such as lysozyme), have shown an apparently insignificant number of intratumoral macrophages. IMAGES:
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spelling pubmed-22464362009-09-10 Macrophages in human breast disease: a quantitative immunohistochemical study. Kelly, P. M. Davison, R. S. Bliss, E. McGee, J. O. Br J Cancer Research Article We describe a quantitative histological study of 34 breast biopsies using a marker for human macrophages, the monoclonal antibody EBM/11. Seventeen of the biopsies were of malignant tumours. Both benign and malignant breast tissue contained large numbers of macrophages with significantly higher numbers occurring in the malignant group. An analysis was made of macrophage counts according to stage, grade and prognostic index of the malignant tumours. There was no correlation between macrophage numbers and any of these parameters in malignant breast tumours. We discuss the possible reasons why some earlier studies (using other markers such as lysozyme), have shown an apparently insignificant number of intratumoral macrophages. IMAGES: Nature Publishing Group 1988-02 /pmc/articles/PMC2246436/ /pubmed/2833921 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kelly, P. M.
Davison, R. S.
Bliss, E.
McGee, J. O.
Macrophages in human breast disease: a quantitative immunohistochemical study.
title Macrophages in human breast disease: a quantitative immunohistochemical study.
title_full Macrophages in human breast disease: a quantitative immunohistochemical study.
title_fullStr Macrophages in human breast disease: a quantitative immunohistochemical study.
title_full_unstemmed Macrophages in human breast disease: a quantitative immunohistochemical study.
title_short Macrophages in human breast disease: a quantitative immunohistochemical study.
title_sort macrophages in human breast disease: a quantitative immunohistochemical study.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246436/
https://www.ncbi.nlm.nih.gov/pubmed/2833921
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AT mcgeejo macrophagesinhumanbreastdiseaseaquantitativeimmunohistochemicalstudy

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