An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.

The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cell...

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Detalles Bibliográficos
Autores principales: Smith, E., Brock, A. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246451/
https://www.ncbi.nlm.nih.gov/pubmed/3044430
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author Smith, E.
Brock, A. P.
author_facet Smith, E.
Brock, A. P.
author_sort Smith, E.
collection PubMed
description The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cells cultured in vitro has been compared. The tumour cell line was much more sensitive to the cytotoxic action of the three agents compared to the CHO cell line. CHIP and carboplatin gave similar dose-response curves, both being much less toxic than cis-platin. The effect of thiol modification on platinum toxicity was also investigated. Substantial reduction in the intracellular non-protein sulphydryl content markedly enhanced the cytotoxicity of CHIP but had much less effect on carboplatin and cis-platin. Thiol depletion by diethylmaleate had a negligible effect on cis-platin toxicity.
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spelling pubmed-22464512009-09-10 An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion. Smith, E. Brock, A. P. Br J Cancer Research Article The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cells cultured in vitro has been compared. The tumour cell line was much more sensitive to the cytotoxic action of the three agents compared to the CHO cell line. CHIP and carboplatin gave similar dose-response curves, both being much less toxic than cis-platin. The effect of thiol modification on platinum toxicity was also investigated. Substantial reduction in the intracellular non-protein sulphydryl content markedly enhanced the cytotoxicity of CHIP but had much less effect on carboplatin and cis-platin. Thiol depletion by diethylmaleate had a negligible effect on cis-platin toxicity. Nature Publishing Group 1988-06 /pmc/articles/PMC2246451/ /pubmed/3044430 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Smith, E.
Brock, A. P.
An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.
title An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.
title_full An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.
title_fullStr An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.
title_full_unstemmed An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.
title_short An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.
title_sort in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246451/
https://www.ncbi.nlm.nih.gov/pubmed/3044430
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