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Does chemotherapy improve survival in advanced breast cancer? A statistical overview.

The relative efficacies of cytotoxic chemotherapy regimens in the treatment of advanced breast cancer are generally assessed by comparing response rates in randomised trials. Treatment attempts to prolong survival but trials rarely demonstrate a statistically significant survival advantage: it has b...

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Detalles Bibliográficos
Autores principales: A'Hern, R. P., Ebbs, S. R., Baum, M. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246459/
https://www.ncbi.nlm.nih.gov/pubmed/3044434
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author A'Hern, R. P.
Ebbs, S. R.
Baum, M. B.
author_facet A'Hern, R. P.
Ebbs, S. R.
Baum, M. B.
author_sort A'Hern, R. P.
collection PubMed
description The relative efficacies of cytotoxic chemotherapy regimens in the treatment of advanced breast cancer are generally assessed by comparing response rates in randomised trials. Treatment attempts to prolong survival but trials rarely demonstrate a statistically significant survival advantage: it has been argued that chemotherapy does not prolong survival. The correlation between response rates and survival has been examined by reviewing 79 comparisons between arms with unequal response rates in 50 published trials of chemotherapy in advanced breast cancer. In 73% of comparisons the group with the higher response rate also demonstrated the longer median survival (P less than 0.001). Weighted linear regression showed a statistically significant relationship between relative response rates and survival (P less than 0.001). The number of patients in a comparison did not influence this relationship.
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spelling pubmed-22464592009-09-10 Does chemotherapy improve survival in advanced breast cancer? A statistical overview. A'Hern, R. P. Ebbs, S. R. Baum, M. B. Br J Cancer Research Article The relative efficacies of cytotoxic chemotherapy regimens in the treatment of advanced breast cancer are generally assessed by comparing response rates in randomised trials. Treatment attempts to prolong survival but trials rarely demonstrate a statistically significant survival advantage: it has been argued that chemotherapy does not prolong survival. The correlation between response rates and survival has been examined by reviewing 79 comparisons between arms with unequal response rates in 50 published trials of chemotherapy in advanced breast cancer. In 73% of comparisons the group with the higher response rate also demonstrated the longer median survival (P less than 0.001). Weighted linear regression showed a statistically significant relationship between relative response rates and survival (P less than 0.001). The number of patients in a comparison did not influence this relationship. Nature Publishing Group 1988-06 /pmc/articles/PMC2246459/ /pubmed/3044434 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
A'Hern, R. P.
Ebbs, S. R.
Baum, M. B.
Does chemotherapy improve survival in advanced breast cancer? A statistical overview.
title Does chemotherapy improve survival in advanced breast cancer? A statistical overview.
title_full Does chemotherapy improve survival in advanced breast cancer? A statistical overview.
title_fullStr Does chemotherapy improve survival in advanced breast cancer? A statistical overview.
title_full_unstemmed Does chemotherapy improve survival in advanced breast cancer? A statistical overview.
title_short Does chemotherapy improve survival in advanced breast cancer? A statistical overview.
title_sort does chemotherapy improve survival in advanced breast cancer? a statistical overview.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246459/
https://www.ncbi.nlm.nih.gov/pubmed/3044434
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