Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.

Levels of the nucleotide pathway enzyme thymidine kinase (TK) were assayed in the mononuclear leukocytes and serum of 70 female patients with breast cancer and 98 male and 77 female non-cancer hospital patients. The total TK levels in both mononuclear leukocytes and serum from patients with breast c...

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Autores principales: McKenna, P. G., O'Neill, K. L., Abram, W. P., Hannigan, B. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246471/
https://www.ncbi.nlm.nih.gov/pubmed/3408646
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author McKenna, P. G.
O'Neill, K. L.
Abram, W. P.
Hannigan, B. M.
author_facet McKenna, P. G.
O'Neill, K. L.
Abram, W. P.
Hannigan, B. M.
author_sort McKenna, P. G.
collection PubMed
description Levels of the nucleotide pathway enzyme thymidine kinase (TK) were assayed in the mononuclear leukocytes and serum of 70 female patients with breast cancer and 98 male and 77 female non-cancer hospital patients. The total TK levels in both mononuclear leukocytes and serum from patients with breast cancer were significantly higher than in controls. The serum TK levels showed a significant correlation with cancer stage. No such correlation was observed with mononuclear leukocyte TK levels. Serum TK from 20 patients with breast cancer and 19 control patients was further assayed to ascertain the relative contributions of the thymidine kinase isozymes TK1 and TK2 to total TK levels. The increase in serum TK from breast cancer patients appears to be due to an increase in both TK1 and TK2 levels.
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spelling pubmed-22464712009-09-10 Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients. McKenna, P. G. O'Neill, K. L. Abram, W. P. Hannigan, B. M. Br J Cancer Research Article Levels of the nucleotide pathway enzyme thymidine kinase (TK) were assayed in the mononuclear leukocytes and serum of 70 female patients with breast cancer and 98 male and 77 female non-cancer hospital patients. The total TK levels in both mononuclear leukocytes and serum from patients with breast cancer were significantly higher than in controls. The serum TK levels showed a significant correlation with cancer stage. No such correlation was observed with mononuclear leukocyte TK levels. Serum TK from 20 patients with breast cancer and 19 control patients was further assayed to ascertain the relative contributions of the thymidine kinase isozymes TK1 and TK2 to total TK levels. The increase in serum TK from breast cancer patients appears to be due to an increase in both TK1 and TK2 levels. Nature Publishing Group 1988-06 /pmc/articles/PMC2246471/ /pubmed/3408646 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
McKenna, P. G.
O'Neill, K. L.
Abram, W. P.
Hannigan, B. M.
Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
title Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
title_full Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
title_fullStr Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
title_full_unstemmed Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
title_short Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
title_sort thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246471/
https://www.ncbi.nlm.nih.gov/pubmed/3408646
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