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Structural and functional aspects of platelet-derived growth factor.

The finding that PDGF production is common in normal as well as transformed cells indicate that PDGF has a function in autocrine and paracrine stimulation of cells in several physiological and pathological conditions. The expression of mRNA for the two chains of PDGF are independently regulated. The...

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Autores principales: Heldin, C. H., Hammacher, A., Nistér, M., Westermark, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246474/
https://www.ncbi.nlm.nih.gov/pubmed/2841963
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author Heldin, C. H.
Hammacher, A.
Nistér, M.
Westermark, B.
author_facet Heldin, C. H.
Hammacher, A.
Nistér, M.
Westermark, B.
author_sort Heldin, C. H.
collection PubMed
description The finding that PDGF production is common in normal as well as transformed cells indicate that PDGF has a function in autocrine and paracrine stimulation of cells in several physiological and pathological conditions. The expression of mRNA for the two chains of PDGF are independently regulated. The fact that the different dimeric forms of PDGF have different functional effects, indicate that the cellular response to PDGF may be more complex than previously thought, and may involve binding to more than one receptor. The cellular effects ascribed to PDGF, growth stimulation, ruffling and chemotaxis, seems to be mainly associated with B chain containing dimers. The function of PDGF-AA remains to be elucidated.
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spelling pubmed-22464742009-09-10 Structural and functional aspects of platelet-derived growth factor. Heldin, C. H. Hammacher, A. Nistér, M. Westermark, B. Br J Cancer Research Article The finding that PDGF production is common in normal as well as transformed cells indicate that PDGF has a function in autocrine and paracrine stimulation of cells in several physiological and pathological conditions. The expression of mRNA for the two chains of PDGF are independently regulated. The fact that the different dimeric forms of PDGF have different functional effects, indicate that the cellular response to PDGF may be more complex than previously thought, and may involve binding to more than one receptor. The cellular effects ascribed to PDGF, growth stimulation, ruffling and chemotaxis, seems to be mainly associated with B chain containing dimers. The function of PDGF-AA remains to be elucidated. Nature Publishing Group 1988-06 /pmc/articles/PMC2246474/ /pubmed/2841963 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Heldin, C. H.
Hammacher, A.
Nistér, M.
Westermark, B.
Structural and functional aspects of platelet-derived growth factor.
title Structural and functional aspects of platelet-derived growth factor.
title_full Structural and functional aspects of platelet-derived growth factor.
title_fullStr Structural and functional aspects of platelet-derived growth factor.
title_full_unstemmed Structural and functional aspects of platelet-derived growth factor.
title_short Structural and functional aspects of platelet-derived growth factor.
title_sort structural and functional aspects of platelet-derived growth factor.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246474/
https://www.ncbi.nlm.nih.gov/pubmed/2841963
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