Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts.

The antitumour activity of flavone acetic acid (FAA) was evaluated against two human colorectal carcinoma (HCC) lines, HCC-P2988 and HCC-M1410, transplanted into nude mice. On repeated i.v. injection of 200 mg kg-1 every 4 days FAA was moderately active against the s.c. growing HCC-P2988. HCC-M1410...

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Autores principales: Giavazzi, R., Garofalo, A., Damia, G., Garattini, S., D'Incalci, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246519/
https://www.ncbi.nlm.nih.gov/pubmed/3355765
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author Giavazzi, R.
Garofalo, A.
Damia, G.
Garattini, S.
D'Incalci, M.
author_facet Giavazzi, R.
Garofalo, A.
Damia, G.
Garattini, S.
D'Incalci, M.
author_sort Giavazzi, R.
collection PubMed
description The antitumour activity of flavone acetic acid (FAA) was evaluated against two human colorectal carcinoma (HCC) lines, HCC-P2988 and HCC-M1410, transplanted into nude mice. On repeated i.v. injection of 200 mg kg-1 every 4 days FAA was moderately active against the s.c. growing HCC-P2988. HCC-M1410 transplanted s.c. was almost unresponsive in the same experimental conditions. In contrast, FAA (200 mg kg-1 i.v. every 4 days, repeated three times) significantly reduced liver tumour colonies produced by the HCC-M1410 cells injected intrasplenically into nude mice. These findings suggest that FAA has potential activity against human colorectal carcinoma, particularly against liver metastases. IMAGES:
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spelling pubmed-22465192009-09-10 Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts. Giavazzi, R. Garofalo, A. Damia, G. Garattini, S. D'Incalci, M. Br J Cancer Research Article The antitumour activity of flavone acetic acid (FAA) was evaluated against two human colorectal carcinoma (HCC) lines, HCC-P2988 and HCC-M1410, transplanted into nude mice. On repeated i.v. injection of 200 mg kg-1 every 4 days FAA was moderately active against the s.c. growing HCC-P2988. HCC-M1410 transplanted s.c. was almost unresponsive in the same experimental conditions. In contrast, FAA (200 mg kg-1 i.v. every 4 days, repeated three times) significantly reduced liver tumour colonies produced by the HCC-M1410 cells injected intrasplenically into nude mice. These findings suggest that FAA has potential activity against human colorectal carcinoma, particularly against liver metastases. IMAGES: Nature Publishing Group 1988-03 /pmc/articles/PMC2246519/ /pubmed/3355765 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Giavazzi, R.
Garofalo, A.
Damia, G.
Garattini, S.
D'Incalci, M.
Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts.
title Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts.
title_full Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts.
title_fullStr Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts.
title_full_unstemmed Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts.
title_short Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts.
title_sort response to flavone acetic acid (nsc 347512) of primary and metastatic human colorectal carcinoma xenografts.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246519/
https://www.ncbi.nlm.nih.gov/pubmed/3355765
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