Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines.

Four human cell lines derived from malignant gliomas were immunohistochemically examined for their content of estramustine-binding protein (EMBP). EMBP was detected in a large amount in all glioma cells during the entire cell cycle. EMBP has previously been demonstrated to be the major receptor prot...

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Detalles Bibliográficos
Autores principales: von Schoultz, E., Lundblad, D., Bergh, J., Grankvist, K., Henriksson, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246581/
https://www.ncbi.nlm.nih.gov/pubmed/3052561
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author von Schoultz, E.
Lundblad, D.
Bergh, J.
Grankvist, K.
Henriksson, R.
author_facet von Schoultz, E.
Lundblad, D.
Bergh, J.
Grankvist, K.
Henriksson, R.
author_sort von Schoultz, E.
collection PubMed
description Four human cell lines derived from malignant gliomas were immunohistochemically examined for their content of estramustine-binding protein (EMBP). EMBP was detected in a large amount in all glioma cells during the entire cell cycle. EMBP has previously been demonstrated to be the major receptor protein in prostatic cancers for the cytostatic drug estramustine-phosphate (EMP). EMP caused a dose-dependent inhibition of exponentially growing cells by increasing the number of cells in G2/M stage of the cell cycle as monitored by flow cytofluorometry. The effect may be coupled to arrest of the glioma cells at metaphase. The presence of EMBP may suggest a selective binding and effect of EMP in glioma cells. IMAGES:
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spelling pubmed-22465812009-09-10 Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines. von Schoultz, E. Lundblad, D. Bergh, J. Grankvist, K. Henriksson, R. Br J Cancer Research Article Four human cell lines derived from malignant gliomas were immunohistochemically examined for their content of estramustine-binding protein (EMBP). EMBP was detected in a large amount in all glioma cells during the entire cell cycle. EMBP has previously been demonstrated to be the major receptor protein in prostatic cancers for the cytostatic drug estramustine-phosphate (EMP). EMP caused a dose-dependent inhibition of exponentially growing cells by increasing the number of cells in G2/M stage of the cell cycle as monitored by flow cytofluorometry. The effect may be coupled to arrest of the glioma cells at metaphase. The presence of EMBP may suggest a selective binding and effect of EMP in glioma cells. IMAGES: Nature Publishing Group 1988-09 /pmc/articles/PMC2246581/ /pubmed/3052561 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
von Schoultz, E.
Lundblad, D.
Bergh, J.
Grankvist, K.
Henriksson, R.
Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines.
title Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines.
title_full Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines.
title_fullStr Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines.
title_full_unstemmed Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines.
title_short Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines.
title_sort estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246581/
https://www.ncbi.nlm.nih.gov/pubmed/3052561
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