Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody.

Monoclonal antibody TFS-4 has previously been shown to react selectively with human small cell lung cancer (SCLC). We evaluated the use of 131I-labelled TFS-4 for the treatment of established human SCLC transplanted in nude mice. The specific accumulation of the antibody in the transplanted tumour w...

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Autores principales: Yoneda, S., Fujisawa, M., Watanabe, J., Okabe, T., Takaku, F., Homma, T., Yoshida, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246584/
https://www.ncbi.nlm.nih.gov/pubmed/2846023
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author Yoneda, S.
Fujisawa, M.
Watanabe, J.
Okabe, T.
Takaku, F.
Homma, T.
Yoshida, K.
author_facet Yoneda, S.
Fujisawa, M.
Watanabe, J.
Okabe, T.
Takaku, F.
Homma, T.
Yoshida, K.
author_sort Yoneda, S.
collection PubMed
description Monoclonal antibody TFS-4 has previously been shown to react selectively with human small cell lung cancer (SCLC). We evaluated the use of 131I-labelled TFS-4 for the treatment of established human SCLC transplanted in nude mice. The specific accumulation of the antibody in the transplanted tumour was recorded by both scintigraphic and biodistribution studies. Administration of 200 microCi 131I-labelled TFS-4 inhibited tumour growth when compared with the same radiation dose of the control monoclonal antibody. The therapeutic effect was dose-dependent and complete disappearance of the tumour was observed transiently in one out of the three animals following the administration of 500 microCi 131I-labelled TFS-4. IMAGES:
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spelling pubmed-22465842009-09-10 Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody. Yoneda, S. Fujisawa, M. Watanabe, J. Okabe, T. Takaku, F. Homma, T. Yoshida, K. Br J Cancer Research Article Monoclonal antibody TFS-4 has previously been shown to react selectively with human small cell lung cancer (SCLC). We evaluated the use of 131I-labelled TFS-4 for the treatment of established human SCLC transplanted in nude mice. The specific accumulation of the antibody in the transplanted tumour was recorded by both scintigraphic and biodistribution studies. Administration of 200 microCi 131I-labelled TFS-4 inhibited tumour growth when compared with the same radiation dose of the control monoclonal antibody. The therapeutic effect was dose-dependent and complete disappearance of the tumour was observed transiently in one out of the three animals following the administration of 500 microCi 131I-labelled TFS-4. IMAGES: Nature Publishing Group 1988-09 /pmc/articles/PMC2246584/ /pubmed/2846023 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Yoneda, S.
Fujisawa, M.
Watanabe, J.
Okabe, T.
Takaku, F.
Homma, T.
Yoshida, K.
Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody.
title Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody.
title_full Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody.
title_fullStr Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody.
title_full_unstemmed Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody.
title_short Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody.
title_sort radioimmunotherapy of transplanted small cell lung cancer with 131i-labelled monoclonal antibody.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246584/
https://www.ncbi.nlm.nih.gov/pubmed/2846023
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