Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).

MAC 16 is one of a series of mouse colon tumours originally induced by dimethylhydrazine. It is a relatively slow growing subcutaneous adenocarcinoma which becomes necrotic as it grows and causes severe body wasting in the host. This study has indicated that the tumour is resistant to a large number...

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Detalles Bibliográficos
Autores principales: Bibby, M. C., Double, J. A., Loadman, P. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246591/
https://www.ncbi.nlm.nih.gov/pubmed/3179187
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author Bibby, M. C.
Double, J. A.
Loadman, P. M.
author_facet Bibby, M. C.
Double, J. A.
Loadman, P. M.
author_sort Bibby, M. C.
collection PubMed
description MAC 16 is one of a series of mouse colon tumours originally induced by dimethylhydrazine. It is a relatively slow growing subcutaneous adenocarcinoma which becomes necrotic as it grows and causes severe body wasting in the host. This study has indicated that the tumour is resistant to a large number of standard anti-cancer drugs but is highly responsive to the investigational agent flavone acetic acid (FAA). The levels of FAA achieved in tumours are lower than those necessary for activity in vitro suggesting its mechanism of action in vivo is not direct cytotoxicity. Responding tumours demonstrate massive tissue necrosis and those which are not cured have viable tumour cells associated with tumour blood vessels. The anti-tumour effects are accompanied by control of the host's cancer cachexia. The unique chemosensitivity of MAC 16 to FAA suggests that this agent has a novel mechanism which may be dependent upon specific biological characteristics of tumours. IMAGES:
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spelling pubmed-22465912009-09-10 Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512). Bibby, M. C. Double, J. A. Loadman, P. M. Br J Cancer Research Article MAC 16 is one of a series of mouse colon tumours originally induced by dimethylhydrazine. It is a relatively slow growing subcutaneous adenocarcinoma which becomes necrotic as it grows and causes severe body wasting in the host. This study has indicated that the tumour is resistant to a large number of standard anti-cancer drugs but is highly responsive to the investigational agent flavone acetic acid (FAA). The levels of FAA achieved in tumours are lower than those necessary for activity in vitro suggesting its mechanism of action in vivo is not direct cytotoxicity. Responding tumours demonstrate massive tissue necrosis and those which are not cured have viable tumour cells associated with tumour blood vessels. The anti-tumour effects are accompanied by control of the host's cancer cachexia. The unique chemosensitivity of MAC 16 to FAA suggests that this agent has a novel mechanism which may be dependent upon specific biological characteristics of tumours. IMAGES: Nature Publishing Group 1988-09 /pmc/articles/PMC2246591/ /pubmed/3179187 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bibby, M. C.
Double, J. A.
Loadman, P. M.
Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).
title Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).
title_full Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).
title_fullStr Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).
title_full_unstemmed Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).
title_short Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).
title_sort unique chemosensitivity of mac 16 tumours to flavone acetic acid (lm975, nsc 347512).
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246591/
https://www.ncbi.nlm.nih.gov/pubmed/3179187
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