Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.

The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type Meth A fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No ot...

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Autores principales: Usami, H., Yamamoto, A., Yamashita, W., Sugawara, Y., Hamada, S., Yamamoto, T., Kato, K., Kokeguchi, S., Ohokuni, H., Kotani, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246679/
https://www.ncbi.nlm.nih.gov/pubmed/3279996
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author Usami, H.
Yamamoto, A.
Yamashita, W.
Sugawara, Y.
Hamada, S.
Yamamoto, T.
Kato, K.
Kokeguchi, S.
Ohokuni, H.
Kotani, S.
author_facet Usami, H.
Yamamoto, A.
Yamashita, W.
Sugawara, Y.
Hamada, S.
Yamamoto, T.
Kato, K.
Kokeguchi, S.
Ohokuni, H.
Kotani, S.
author_sort Usami, H.
collection PubMed
description The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type Meth A fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of Meth A. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on Meth A cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.
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spelling pubmed-22466792009-09-10 Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma. Usami, H. Yamamoto, A. Yamashita, W. Sugawara, Y. Hamada, S. Yamamoto, T. Kato, K. Kokeguchi, S. Ohokuni, H. Kotani, S. Br J Cancer Research Article The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type Meth A fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of Meth A. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on Meth A cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF. Nature Publishing Group 1988-01 /pmc/articles/PMC2246679/ /pubmed/3279996 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Usami, H.
Yamamoto, A.
Yamashita, W.
Sugawara, Y.
Hamada, S.
Yamamoto, T.
Kato, K.
Kokeguchi, S.
Ohokuni, H.
Kotani, S.
Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.
title Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.
title_full Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.
title_fullStr Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.
title_full_unstemmed Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.
title_short Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.
title_sort antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246679/
https://www.ncbi.nlm.nih.gov/pubmed/3279996
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