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The treatment of advanced seminoma with chemotherapy and radiotherapy.
Between 1979 and 1984 thirty-seven patients were treated with combination chemotherapy for metastatic seminoma; 27 of these had relapsed following initial radiotherapy for stage I and IIA disease and 10 patients with stage IIB-IV disease received chemotherapy de novo followed by radiotherapy to site...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1988
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246680/ https://www.ncbi.nlm.nih.gov/pubmed/2450555 |
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author | Wilkinson, P. M. Read, G. Magee, B. |
author_facet | Wilkinson, P. M. Read, G. Magee, B. |
author_sort | Wilkinson, P. M. |
collection | PubMed |
description | Between 1979 and 1984 thirty-seven patients were treated with combination chemotherapy for metastatic seminoma; 27 of these had relapsed following initial radiotherapy for stage I and IIA disease and 10 patients with stage IIB-IV disease received chemotherapy de novo followed by radiotherapy to sites of bulk disease. Treatment consisted of either a cis-platinum containing combination (25 patients), or cyclophosphamide and etoposide (12 patients). The overall survival of all patients at 5 years was 49%, 34 patients were assessable for response; a CR was obtained in 8 (24%) and a GPR in 19 (56%), the 5 year survival of this group being 66% at 5 years. No difference in survival was seen in relation to age, previous irradiation, serum HCG or LDH; bulk disease however, was an adverse prognostic factor. Survival was similar for both chemotherapy schedules but neutropenia and life-threatening sepsis was less with the cyclophosphamide etoposide combination. |
format | Text |
id | pubmed-2246680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1988 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-22466802009-09-10 The treatment of advanced seminoma with chemotherapy and radiotherapy. Wilkinson, P. M. Read, G. Magee, B. Br J Cancer Research Article Between 1979 and 1984 thirty-seven patients were treated with combination chemotherapy for metastatic seminoma; 27 of these had relapsed following initial radiotherapy for stage I and IIA disease and 10 patients with stage IIB-IV disease received chemotherapy de novo followed by radiotherapy to sites of bulk disease. Treatment consisted of either a cis-platinum containing combination (25 patients), or cyclophosphamide and etoposide (12 patients). The overall survival of all patients at 5 years was 49%, 34 patients were assessable for response; a CR was obtained in 8 (24%) and a GPR in 19 (56%), the 5 year survival of this group being 66% at 5 years. No difference in survival was seen in relation to age, previous irradiation, serum HCG or LDH; bulk disease however, was an adverse prognostic factor. Survival was similar for both chemotherapy schedules but neutropenia and life-threatening sepsis was less with the cyclophosphamide etoposide combination. Nature Publishing Group 1988-01 /pmc/articles/PMC2246680/ /pubmed/2450555 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Wilkinson, P. M. Read, G. Magee, B. The treatment of advanced seminoma with chemotherapy and radiotherapy. |
title | The treatment of advanced seminoma with chemotherapy and radiotherapy. |
title_full | The treatment of advanced seminoma with chemotherapy and radiotherapy. |
title_fullStr | The treatment of advanced seminoma with chemotherapy and radiotherapy. |
title_full_unstemmed | The treatment of advanced seminoma with chemotherapy and radiotherapy. |
title_short | The treatment of advanced seminoma with chemotherapy and radiotherapy. |
title_sort | treatment of advanced seminoma with chemotherapy and radiotherapy. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246680/ https://www.ncbi.nlm.nih.gov/pubmed/2450555 |
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