Interaction of the novel agent amphethinile with tubulin.

The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but not vinblastine from tubulin and causes a stimulation in GTPase activity in vitro. The affinity constant for the association of this drug with tubulin has been determined (K...

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Detalles Bibliográficos
Autores principales: McGown, A. T., Fox, B. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246728/
https://www.ncbi.nlm.nih.gov/pubmed/2736224
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author McGown, A. T.
Fox, B. W.
author_facet McGown, A. T.
Fox, B. W.
author_sort McGown, A. T.
collection PubMed
description The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but not vinblastine from tubulin and causes a stimulation in GTPase activity in vitro. The affinity constant for the association of this drug with tubulin has been determined (Ka = 1.3 x 10(6) M-1). It is concluded that amphethinile belongs to the class of agents which share a common binding site with colchicine on the tubulin molecule.
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spelling pubmed-22467282009-09-10 Interaction of the novel agent amphethinile with tubulin. McGown, A. T. Fox, B. W. Br J Cancer Research Article The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but not vinblastine from tubulin and causes a stimulation in GTPase activity in vitro. The affinity constant for the association of this drug with tubulin has been determined (Ka = 1.3 x 10(6) M-1). It is concluded that amphethinile belongs to the class of agents which share a common binding site with colchicine on the tubulin molecule. Nature Publishing Group 1989-06 /pmc/articles/PMC2246728/ /pubmed/2736224 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
McGown, A. T.
Fox, B. W.
Interaction of the novel agent amphethinile with tubulin.
title Interaction of the novel agent amphethinile with tubulin.
title_full Interaction of the novel agent amphethinile with tubulin.
title_fullStr Interaction of the novel agent amphethinile with tubulin.
title_full_unstemmed Interaction of the novel agent amphethinile with tubulin.
title_short Interaction of the novel agent amphethinile with tubulin.
title_sort interaction of the novel agent amphethinile with tubulin.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246728/
https://www.ncbi.nlm.nih.gov/pubmed/2736224
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