Epidermal growth factor receptor status of histological sub-types of breast cancer.

The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours cont...

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Autores principales: Sainsbury, J. R., Nicholson, S., Angus, B., Farndon, J. R., Malcolm, A. J., Harris, A. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246782/
https://www.ncbi.nlm.nih.gov/pubmed/3207600
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author Sainsbury, J. R.
Nicholson, S.
Angus, B.
Farndon, J. R.
Malcolm, A. J.
Harris, A. L.
author_facet Sainsbury, J. R.
Nicholson, S.
Angus, B.
Farndon, J. R.
Malcolm, A. J.
Harris, A. L.
author_sort Sainsbury, J. R.
collection PubMed
description The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptors have all recurred within two years of resection. Twenty-one percent of the lobular carcinomas contained EGF receptors compared to 34% of ductal carcinomas. EGF receptor status appeared to be associated with an increased risk of early recurrence and death whatever the histological sub-type of the breast cancer.
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spelling pubmed-22467822009-09-10 Epidermal growth factor receptor status of histological sub-types of breast cancer. Sainsbury, J. R. Nicholson, S. Angus, B. Farndon, J. R. Malcolm, A. J. Harris, A. L. Br J Cancer Research Article The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptors have all recurred within two years of resection. Twenty-one percent of the lobular carcinomas contained EGF receptors compared to 34% of ductal carcinomas. EGF receptor status appeared to be associated with an increased risk of early recurrence and death whatever the histological sub-type of the breast cancer. Nature Publishing Group 1988-10 /pmc/articles/PMC2246782/ /pubmed/3207600 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sainsbury, J. R.
Nicholson, S.
Angus, B.
Farndon, J. R.
Malcolm, A. J.
Harris, A. L.
Epidermal growth factor receptor status of histological sub-types of breast cancer.
title Epidermal growth factor receptor status of histological sub-types of breast cancer.
title_full Epidermal growth factor receptor status of histological sub-types of breast cancer.
title_fullStr Epidermal growth factor receptor status of histological sub-types of breast cancer.
title_full_unstemmed Epidermal growth factor receptor status of histological sub-types of breast cancer.
title_short Epidermal growth factor receptor status of histological sub-types of breast cancer.
title_sort epidermal growth factor receptor status of histological sub-types of breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246782/
https://www.ncbi.nlm.nih.gov/pubmed/3207600
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