In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.

The evolution of in vitro bone marrow clonogenic leukaemic cells (CFU-L) drug sensitivity was studied in 23 patients with acute myeloid leukaemia treated with anthracycline and cytosine arbinoside (ara-C). In 12 patients tested before and after first induction treatment failure (interval: 6 +/- 4 we...

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Autores principales: Marie, J. P., Zittoun, R., Thevenin, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246830/
https://www.ncbi.nlm.nih.gov/pubmed/3219266
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author Marie, J. P.
Zittoun, R.
Thevenin, D.
author_facet Marie, J. P.
Zittoun, R.
Thevenin, D.
author_sort Marie, J. P.
collection PubMed
description The evolution of in vitro bone marrow clonogenic leukaemic cells (CFU-L) drug sensitivity was studied in 23 patients with acute myeloid leukaemia treated with anthracycline and cytosine arbinoside (ara-C). In 12 patients tested before and after first induction treatment failure (interval: 6 +/- 4 weeks), the sensitivity remained stable for daunorubicin and showed little variation for ara-C. Among eleven patients tested before treatment and at first relapse (interval: 13 +/- 7 months), in vitro CFU-L sensitivity revealed no correlation between the two measurements, and a trend in decreased sensitivity to daunorubicin and ara-C. These findings suggest that induction failures could be related to factors other than simple selection of a resistant CFU-L subclone.
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spelling pubmed-22468302009-09-10 In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia. Marie, J. P. Zittoun, R. Thevenin, D. Br J Cancer Research Article The evolution of in vitro bone marrow clonogenic leukaemic cells (CFU-L) drug sensitivity was studied in 23 patients with acute myeloid leukaemia treated with anthracycline and cytosine arbinoside (ara-C). In 12 patients tested before and after first induction treatment failure (interval: 6 +/- 4 weeks), the sensitivity remained stable for daunorubicin and showed little variation for ara-C. Among eleven patients tested before treatment and at first relapse (interval: 13 +/- 7 months), in vitro CFU-L sensitivity revealed no correlation between the two measurements, and a trend in decreased sensitivity to daunorubicin and ara-C. These findings suggest that induction failures could be related to factors other than simple selection of a resistant CFU-L subclone. Nature Publishing Group 1988-11 /pmc/articles/PMC2246830/ /pubmed/3219266 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Marie, J. P.
Zittoun, R.
Thevenin, D.
In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.
title In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.
title_full In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.
title_fullStr In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.
title_full_unstemmed In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.
title_short In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.
title_sort in vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246830/
https://www.ncbi.nlm.nih.gov/pubmed/3219266
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