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A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite.
Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possess...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1988
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246831/ https://www.ncbi.nlm.nih.gov/pubmed/2851310 |
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author | Steven, F. S. Hill, R. J. |
author_facet | Steven, F. S. Hill, R. J. |
author_sort | Steven, F. S. |
collection | PubMed |
description | Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We have employed this fluorescent probe technique to follow the early events in the lungs of rats exposed to erionite. The evidence presented shows that the mesothelial cells initially lack this enzyme but the enzyme can be detected within hours of exposure of the rat to erionite. The number of mesothelial cells possessing the enzyme steadily increased after a single exposure to the mineral until the animal finally died with a massive pleural tumour. This is the first study of such fluorescent probes in the early stages of tumour induction. IMAGES: |
format | Text |
id | pubmed-2246831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1988 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-22468312009-09-10 A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite. Steven, F. S. Hill, R. J. Br J Cancer Research Article Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We have employed this fluorescent probe technique to follow the early events in the lungs of rats exposed to erionite. The evidence presented shows that the mesothelial cells initially lack this enzyme but the enzyme can be detected within hours of exposure of the rat to erionite. The number of mesothelial cells possessing the enzyme steadily increased after a single exposure to the mineral until the animal finally died with a massive pleural tumour. This is the first study of such fluorescent probes in the early stages of tumour induction. IMAGES: Nature Publishing Group 1988-11 /pmc/articles/PMC2246831/ /pubmed/2851310 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Steven, F. S. Hill, R. J. A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite. |
title | A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite. |
title_full | A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite. |
title_fullStr | A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite. |
title_full_unstemmed | A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite. |
title_short | A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite. |
title_sort | study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246831/ https://www.ncbi.nlm.nih.gov/pubmed/2851310 |
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