Progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice.

A human malignant pleural mesothelioma was xenografted serially in athymic nude Rowett rats for 27 passages during 33 months. After the two initial passages (P), the take rate during P3-9 was 100% (192/192). The tumour grew progressively during P3-9 in 99% (190/192) and regressed totally in 1% (2/19...

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Autores principales: Lindén, C. J., Johansson, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246841/
https://www.ncbi.nlm.nih.gov/pubmed/3219271
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author Lindén, C. J.
Johansson, L.
author_facet Lindén, C. J.
Johansson, L.
author_sort Lindén, C. J.
collection PubMed
description A human malignant pleural mesothelioma was xenografted serially in athymic nude Rowett rats for 27 passages during 33 months. After the two initial passages (P), the take rate during P3-9 was 100% (192/192). The tumour grew progressively during P3-9 in 99% (190/192) and regressed totally in 1% (2/192). The take rate for the tumour xenografted to athymic BALB/c mice was also 100% (17/17) and no regressions were observed. During serial passaging in nude rats, the tumour-volume doubling time (TD) decreased from 6 days in P2 to 3 days in P8-9 (P less than 0.001) and then remained around 3 days during P10-25. A TD of 11 days in P1 (man-mouse) for tumours grown in mice decreased during 10 passages in rats to 4 days (P less than 0.005) when the tumour was transplanted to mice in P11. Light microscopic morphology of the tumour was retained in rats and mice. We believe that our experimental tumour model using the nude rat as a carrier of the xenograft will be useful for studies of human mesothelioma. IMAGES:
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spelling pubmed-22468412009-09-10 Progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice. Lindén, C. J. Johansson, L. Br J Cancer Research Article A human malignant pleural mesothelioma was xenografted serially in athymic nude Rowett rats for 27 passages during 33 months. After the two initial passages (P), the take rate during P3-9 was 100% (192/192). The tumour grew progressively during P3-9 in 99% (190/192) and regressed totally in 1% (2/192). The take rate for the tumour xenografted to athymic BALB/c mice was also 100% (17/17) and no regressions were observed. During serial passaging in nude rats, the tumour-volume doubling time (TD) decreased from 6 days in P2 to 3 days in P8-9 (P less than 0.001) and then remained around 3 days during P10-25. A TD of 11 days in P1 (man-mouse) for tumours grown in mice decreased during 10 passages in rats to 4 days (P less than 0.005) when the tumour was transplanted to mice in P11. Light microscopic morphology of the tumour was retained in rats and mice. We believe that our experimental tumour model using the nude rat as a carrier of the xenograft will be useful for studies of human mesothelioma. IMAGES: Nature Publishing Group 1988-11 /pmc/articles/PMC2246841/ /pubmed/3219271 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Lindén, C. J.
Johansson, L.
Progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice.
title Progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice.
title_full Progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice.
title_fullStr Progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice.
title_full_unstemmed Progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice.
title_short Progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice.
title_sort progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246841/
https://www.ncbi.nlm.nih.gov/pubmed/3219271
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