Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours.

The presence of a number of regulatory peptides (bombesin, gastrin, glucagon, somatostatin, calcitonin and ACTH) was compared in 30 typical carcinoid tumours and 27 well differentiated neuroendocrine carcinomas (atypical carcinoids) using conventional immunocytochemistry. Strong immunostaining for o...

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Autores principales: al-Saffar, N., White, A., Moore, M., Hasleton, P. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246861/
https://www.ncbi.nlm.nih.gov/pubmed/2906252
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author al-Saffar, N.
White, A.
Moore, M.
Hasleton, P. S.
author_facet al-Saffar, N.
White, A.
Moore, M.
Hasleton, P. S.
author_sort al-Saffar, N.
collection PubMed
description The presence of a number of regulatory peptides (bombesin, gastrin, glucagon, somatostatin, calcitonin and ACTH) was compared in 30 typical carcinoid tumours and 27 well differentiated neuroendocrine carcinomas (atypical carcinoids) using conventional immunocytochemistry. Strong immunostaining for one or more peptide was observed in 97% of the typical carcinoids (29/30) whereas only 67% of the neuroendocrine carcinomas showed immunoreactivity. The peptide most frequently detected in typical carcinoids was bombesin (67%), while gastrin was more common in neuroendocrine carcinomas (44%). Immunoreactivity for more than one peptide was present in 33 tumours and in three cases, six different peptides were detected. The study shows that immunoreactivity to various peptides is more common in typical carcinoids than well differentiated neuroendocrine carcinomas. The significance of these findings is discussed. IMAGES:
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spelling pubmed-22468612009-09-10 Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours. al-Saffar, N. White, A. Moore, M. Hasleton, P. S. Br J Cancer Research Article The presence of a number of regulatory peptides (bombesin, gastrin, glucagon, somatostatin, calcitonin and ACTH) was compared in 30 typical carcinoid tumours and 27 well differentiated neuroendocrine carcinomas (atypical carcinoids) using conventional immunocytochemistry. Strong immunostaining for one or more peptide was observed in 97% of the typical carcinoids (29/30) whereas only 67% of the neuroendocrine carcinomas showed immunoreactivity. The peptide most frequently detected in typical carcinoids was bombesin (67%), while gastrin was more common in neuroendocrine carcinomas (44%). Immunoreactivity for more than one peptide was present in 33 tumours and in three cases, six different peptides were detected. The study shows that immunoreactivity to various peptides is more common in typical carcinoids than well differentiated neuroendocrine carcinomas. The significance of these findings is discussed. IMAGES: Nature Publishing Group 1988-12 /pmc/articles/PMC2246861/ /pubmed/2906252 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
al-Saffar, N.
White, A.
Moore, M.
Hasleton, P. S.
Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours.
title Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours.
title_full Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours.
title_fullStr Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours.
title_full_unstemmed Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours.
title_short Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours.
title_sort immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246861/
https://www.ncbi.nlm.nih.gov/pubmed/2906252
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AT hasletonps immunoreactivityofvariouspeptidesintypicalandatypicalbronchopulmonarycarcinoidtumours

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