Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney.

The Wilms' tumour is a solid childhood tumour of the kidney, consisting of blastema, tubules and mesenchyme. Embryonic tumours, such as Wilms', may arise as a result of a developmental disturbance in differentiation. The expression of class I and II major histocompatibility complex (MHC) a...

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Autores principales: Borthwick, G. M., Hughes, L., Holmes, C. H., Davis, S. J., Stirrat, G. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246863/
https://www.ncbi.nlm.nih.gov/pubmed/2465017
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author Borthwick, G. M.
Hughes, L.
Holmes, C. H.
Davis, S. J.
Stirrat, G. M.
author_facet Borthwick, G. M.
Hughes, L.
Holmes, C. H.
Davis, S. J.
Stirrat, G. M.
author_sort Borthwick, G. M.
collection PubMed
description The Wilms' tumour is a solid childhood tumour of the kidney, consisting of blastema, tubules and mesenchyme. Embryonic tumours, such as Wilms', may arise as a result of a developmental disturbance in differentiation. The expression of class I and II major histocompatibility complex (MHC) antigens was investigated on 6 Wilms' tumours and related to that in the developing human kidney in this immunohistological study, using a panel of monoclonal antibodies. The Wilms' tumour blastemal cells were class I MHC antigen negative, but differentiated structures were positive. Class II MHC antigens were not observed in Wilms' tumours. In the developing human kidney class I MHC antigen expression was observed on glomeruli from 8 weeks and on tubules from 13 weeks gestational age. Class II MHC antigen expression was observed on glomeruli from 11 weeks and on tubules from 13 weeks gestation. These results suggest that the blastemal cells within the Wilms' tumour may reflect an early stage of development with respect to the expression of MHC antigens. IMAGES:
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spelling pubmed-22468632009-09-10 Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney. Borthwick, G. M. Hughes, L. Holmes, C. H. Davis, S. J. Stirrat, G. M. Br J Cancer Research Article The Wilms' tumour is a solid childhood tumour of the kidney, consisting of blastema, tubules and mesenchyme. Embryonic tumours, such as Wilms', may arise as a result of a developmental disturbance in differentiation. The expression of class I and II major histocompatibility complex (MHC) antigens was investigated on 6 Wilms' tumours and related to that in the developing human kidney in this immunohistological study, using a panel of monoclonal antibodies. The Wilms' tumour blastemal cells were class I MHC antigen negative, but differentiated structures were positive. Class II MHC antigens were not observed in Wilms' tumours. In the developing human kidney class I MHC antigen expression was observed on glomeruli from 8 weeks and on tubules from 13 weeks gestational age. Class II MHC antigen expression was observed on glomeruli from 11 weeks and on tubules from 13 weeks gestation. These results suggest that the blastemal cells within the Wilms' tumour may reflect an early stage of development with respect to the expression of MHC antigens. IMAGES: Nature Publishing Group 1988-12 /pmc/articles/PMC2246863/ /pubmed/2465017 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Borthwick, G. M.
Hughes, L.
Holmes, C. H.
Davis, S. J.
Stirrat, G. M.
Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney.
title Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney.
title_full Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney.
title_fullStr Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney.
title_full_unstemmed Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney.
title_short Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney.
title_sort expression of class i and ii major histocompatibility complex antigens in wilms' tumour and normal developing human kidney.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246863/
https://www.ncbi.nlm.nih.gov/pubmed/2465017
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