Cargando…
A cytotoxic agent can be generated selectively at cancer sites.
Attempts to improve the selectivity of anti-cancer agents by conjugating them to antibodies directed at tumour associated antigens have demonstrated tumour localisation but only limited therapeutic success. We report here the advantage of a 2-stage approach in which the first component combines the...
Autores principales: | Bagshawe, K. D., Springer, C. J., Searle, F., Antoniw, P., Sharma, S. K., Melton, R. G., Sherwood, R. F. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1988
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246864/ https://www.ncbi.nlm.nih.gov/pubmed/3265633 |
Ejemplares similares
-
Disposition of the prodrug 4-(bis (2-chloroethyl) amino) benzoyl-L-glutamic acid and its active parent drug in mice.
por: Antoniw, P., et al.
Publicado: (1990) -
The First Bagshawe lecture. Towards generating cytotoxic agents at cancer sites.
por: Bagshawe, K. D.
Publicado: (1989) -
The potential of carboxypeptidase G2: antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model.
por: Melton, R. G., et al.
Publicado: (1990) -
The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro.
por: Searle, F., et al.
Publicado: (1986) -
Intensive Cytotoxic Chemotherapy
por: Bagshawe, K. D.
Publicado: (1971)