The prognostic influence of serum neuron specific enolase in small cell lung cancer.

An analysis of prognostic factors in small cell lung cancer has been made using presentation data from 86 of 101 consecutive patients referred to The Finsen Institute for chemotherapy. Prognosis was in univariate analysis significantly correlated with performance status (PS), disease extent, serum l...

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Detalles Bibliográficos
Autores principales: Jørgensen, L. G., Osterlind, K., Hansen, H. H., Cooper, E. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246866/
https://www.ncbi.nlm.nih.gov/pubmed/2852029
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author Jørgensen, L. G.
Osterlind, K.
Hansen, H. H.
Cooper, E. H.
author_facet Jørgensen, L. G.
Osterlind, K.
Hansen, H. H.
Cooper, E. H.
author_sort Jørgensen, L. G.
collection PubMed
description An analysis of prognostic factors in small cell lung cancer has been made using presentation data from 86 of 101 consecutive patients referred to The Finsen Institute for chemotherapy. Prognosis was in univariate analysis significantly correlated with performance status (PS), disease extent, serum lactate dehydrogenase (LDH), neuron specific enolase (NSE), alpha-1-acid glycoprotein and plasma sodium. Multivariate analysis, taking stage of disease into account, resulted in selection of PS and NSE as the most influential of the investigated variables. LDH was excluded as an independent prognosticator, but there was a strong correlation between the influence of LDH and NSE (coefficient: -0.38) as well as between their serum concentrations (coefficient: 0.72). LDH and NSE apparently have similar prognostic influence, and NSE seems superior to LDH. A firm conclusion should, however, await our investigation of a large series of patients.
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spelling pubmed-22468662009-09-10 The prognostic influence of serum neuron specific enolase in small cell lung cancer. Jørgensen, L. G. Osterlind, K. Hansen, H. H. Cooper, E. H. Br J Cancer Research Article An analysis of prognostic factors in small cell lung cancer has been made using presentation data from 86 of 101 consecutive patients referred to The Finsen Institute for chemotherapy. Prognosis was in univariate analysis significantly correlated with performance status (PS), disease extent, serum lactate dehydrogenase (LDH), neuron specific enolase (NSE), alpha-1-acid glycoprotein and plasma sodium. Multivariate analysis, taking stage of disease into account, resulted in selection of PS and NSE as the most influential of the investigated variables. LDH was excluded as an independent prognosticator, but there was a strong correlation between the influence of LDH and NSE (coefficient: -0.38) as well as between their serum concentrations (coefficient: 0.72). LDH and NSE apparently have similar prognostic influence, and NSE seems superior to LDH. A firm conclusion should, however, await our investigation of a large series of patients. Nature Publishing Group 1988-12 /pmc/articles/PMC2246866/ /pubmed/2852029 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Jørgensen, L. G.
Osterlind, K.
Hansen, H. H.
Cooper, E. H.
The prognostic influence of serum neuron specific enolase in small cell lung cancer.
title The prognostic influence of serum neuron specific enolase in small cell lung cancer.
title_full The prognostic influence of serum neuron specific enolase in small cell lung cancer.
title_fullStr The prognostic influence of serum neuron specific enolase in small cell lung cancer.
title_full_unstemmed The prognostic influence of serum neuron specific enolase in small cell lung cancer.
title_short The prognostic influence of serum neuron specific enolase in small cell lung cancer.
title_sort prognostic influence of serum neuron specific enolase in small cell lung cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246866/
https://www.ncbi.nlm.nih.gov/pubmed/2852029
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