Reassessment of the relationship between M-protein decrement and survival in multiple myeloma.

The relationship between percentage M-protein decrement and survival is assessed in 134 multiple myeloma patients. The correlation did not achieve statistical significance (P = 0.069). Multivariate analysis using the Cox proportional hazards model, including a number of previously recognised prognos...

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Autores principales: Palmer, M., Belch, A., Hanson, J., Brox, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246972/
https://www.ncbi.nlm.nih.gov/pubmed/2757916
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author Palmer, M.
Belch, A.
Hanson, J.
Brox, L.
author_facet Palmer, M.
Belch, A.
Hanson, J.
Brox, L.
author_sort Palmer, M.
collection PubMed
description The relationship between percentage M-protein decrement and survival is assessed in 134 multiple myeloma patients. The correlation did not achieve statistical significance (P = 0.069). Multivariate analysis using the Cox proportional hazards model, including a number of previously recognised prognostic factors, showed only percentage M-protein decrement, creatinine and haemoglobin to be significantly correlated with survival. However, the R'-statistic for each of these variables was low, indicating that their prognostic power is weak. We conclude that neither the percentage M-protein decrement nor the response derived from it can be used as an accurate means of assessing the efficacy of treatment in myeloma. Mature survival data alone should be used for this purpose.
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spelling pubmed-22469722009-09-10 Reassessment of the relationship between M-protein decrement and survival in multiple myeloma. Palmer, M. Belch, A. Hanson, J. Brox, L. Br J Cancer Research Article The relationship between percentage M-protein decrement and survival is assessed in 134 multiple myeloma patients. The correlation did not achieve statistical significance (P = 0.069). Multivariate analysis using the Cox proportional hazards model, including a number of previously recognised prognostic factors, showed only percentage M-protein decrement, creatinine and haemoglobin to be significantly correlated with survival. However, the R'-statistic for each of these variables was low, indicating that their prognostic power is weak. We conclude that neither the percentage M-protein decrement nor the response derived from it can be used as an accurate means of assessing the efficacy of treatment in myeloma. Mature survival data alone should be used for this purpose. Nature Publishing Group 1989-01 /pmc/articles/PMC2246972/ /pubmed/2757916 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Palmer, M.
Belch, A.
Hanson, J.
Brox, L.
Reassessment of the relationship between M-protein decrement and survival in multiple myeloma.
title Reassessment of the relationship between M-protein decrement and survival in multiple myeloma.
title_full Reassessment of the relationship between M-protein decrement and survival in multiple myeloma.
title_fullStr Reassessment of the relationship between M-protein decrement and survival in multiple myeloma.
title_full_unstemmed Reassessment of the relationship between M-protein decrement and survival in multiple myeloma.
title_short Reassessment of the relationship between M-protein decrement and survival in multiple myeloma.
title_sort reassessment of the relationship between m-protein decrement and survival in multiple myeloma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246972/
https://www.ncbi.nlm.nih.gov/pubmed/2757916
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AT hansonj reassessmentoftherelationshipbetweenmproteindecrementandsurvivalinmultiplemyeloma
AT broxl reassessmentoftherelationshipbetweenmproteindecrementandsurvivalinmultiplemyeloma

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