High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.

Symptomatic brain metastases are found in about 40% of patients with small cell lung cancer. Cranial irradiation is the first line treatment for this form of metastatic disease. Frequently brain metastases recur after this treatment or develop after prophylactic cranial irradiation. For these patien...

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Autores principales: Postmus, P. E., Haaxma-Reiche, H., Sleijfer, D. T., Kirkpatrick, A., McVie, J. G., Kleisbauer, J. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246989/
https://www.ncbi.nlm.nih.gov/pubmed/2539174
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author Postmus, P. E.
Haaxma-Reiche, H.
Sleijfer, D. T.
Kirkpatrick, A.
McVie, J. G.
Kleisbauer, J. P.
author_facet Postmus, P. E.
Haaxma-Reiche, H.
Sleijfer, D. T.
Kirkpatrick, A.
McVie, J. G.
Kleisbauer, J. P.
author_sort Postmus, P. E.
collection PubMed
description Symptomatic brain metastases are found in about 40% of patients with small cell lung cancer. Cranial irradiation is the first line treatment for this form of metastatic disease. Frequently brain metastases recur after this treatment or develop after prophylactic cranial irradiation. For these patients no effective antitumour therapy is available. In this study the efficacy of high dose etoposide 1.5 g m-2 was evaluated. In 10 (43%) out of 23 evaluable patients a response was seen. Toxicity was severe with five aplasia-related deaths. For palliative purposes this regimen is too toxic in heavily pretreated patients.
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spelling pubmed-22469892009-09-10 High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group. Postmus, P. E. Haaxma-Reiche, H. Sleijfer, D. T. Kirkpatrick, A. McVie, J. G. Kleisbauer, J. P. Br J Cancer Research Article Symptomatic brain metastases are found in about 40% of patients with small cell lung cancer. Cranial irradiation is the first line treatment for this form of metastatic disease. Frequently brain metastases recur after this treatment or develop after prophylactic cranial irradiation. For these patients no effective antitumour therapy is available. In this study the efficacy of high dose etoposide 1.5 g m-2 was evaluated. In 10 (43%) out of 23 evaluable patients a response was seen. Toxicity was severe with five aplasia-related deaths. For palliative purposes this regimen is too toxic in heavily pretreated patients. Nature Publishing Group 1989-02 /pmc/articles/PMC2246989/ /pubmed/2539174 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Postmus, P. E.
Haaxma-Reiche, H.
Sleijfer, D. T.
Kirkpatrick, A.
McVie, J. G.
Kleisbauer, J. P.
High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.
title High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.
title_full High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.
title_fullStr High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.
title_full_unstemmed High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.
title_short High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.
title_sort high dose etoposide for brain metastases of small cell lung cancer. a phase ii study. the eortc lung cancer cooperative group.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246989/
https://www.ncbi.nlm.nih.gov/pubmed/2539174
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