Prognostic relevance of DNA content in childhood renal tumours.

The DNA content of paraffin embedded tumour specimens from 100 children with kidney tumours was studied by flow cytometry. Data of adequate quality were obtained from 93 cases comprising 67 Wilms' tumours with a favourable histology (FH), 12 Wilms' tumours with unfavourable histology (UH)...

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Autores principales: Kumar, S., Marsden, H. B., Cowan, R. A., Barnes, J. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247016/
https://www.ncbi.nlm.nih.gov/pubmed/2539176
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author Kumar, S.
Marsden, H. B.
Cowan, R. A.
Barnes, J. M.
author_facet Kumar, S.
Marsden, H. B.
Cowan, R. A.
Barnes, J. M.
author_sort Kumar, S.
collection PubMed
description The DNA content of paraffin embedded tumour specimens from 100 children with kidney tumours was studied by flow cytometry. Data of adequate quality were obtained from 93 cases comprising 67 Wilms' tumours with a favourable histology (FH), 12 Wilms' tumours with unfavourable histology (UH) (pleomorphic), 8 bone-metastasising renal tumours of childhood (BMRTC) and 6 rhabdoid renal tumours. Only 4.5% FH compared with 75% UH Wilms' were aneuploid (P less than 0.001). Although BMRTC and rhabdoid tumours are associated with poor prognosis, there were no examples of aneuploidy in these tumours. The proliferation index was found to be of no prognostic value. Staging and ploidy were not correlated with each other in any of the various histological types of renal tumours studied.
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spelling pubmed-22470162009-09-10 Prognostic relevance of DNA content in childhood renal tumours. Kumar, S. Marsden, H. B. Cowan, R. A. Barnes, J. M. Br J Cancer Research Article The DNA content of paraffin embedded tumour specimens from 100 children with kidney tumours was studied by flow cytometry. Data of adequate quality were obtained from 93 cases comprising 67 Wilms' tumours with a favourable histology (FH), 12 Wilms' tumours with unfavourable histology (UH) (pleomorphic), 8 bone-metastasising renal tumours of childhood (BMRTC) and 6 rhabdoid renal tumours. Only 4.5% FH compared with 75% UH Wilms' were aneuploid (P less than 0.001). Although BMRTC and rhabdoid tumours are associated with poor prognosis, there were no examples of aneuploidy in these tumours. The proliferation index was found to be of no prognostic value. Staging and ploidy were not correlated with each other in any of the various histological types of renal tumours studied. Nature Publishing Group 1989-02 /pmc/articles/PMC2247016/ /pubmed/2539176 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kumar, S.
Marsden, H. B.
Cowan, R. A.
Barnes, J. M.
Prognostic relevance of DNA content in childhood renal tumours.
title Prognostic relevance of DNA content in childhood renal tumours.
title_full Prognostic relevance of DNA content in childhood renal tumours.
title_fullStr Prognostic relevance of DNA content in childhood renal tumours.
title_full_unstemmed Prognostic relevance of DNA content in childhood renal tumours.
title_short Prognostic relevance of DNA content in childhood renal tumours.
title_sort prognostic relevance of dna content in childhood renal tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247016/
https://www.ncbi.nlm.nih.gov/pubmed/2539176
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AT barnesjm prognosticrelevanceofdnacontentinchildhoodrenaltumours

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