In vivo magnetic resonance imaging of the effects of photodynamic therapy.

Nuclear magnetic resonance (NMR) proton imaging and measurements of the parameters T1 and T2, have been carried out in vivo on the murine mammary tumour T50/80. Tumours had been treated 24 h previously by photodynamic therapy (PDT, using haematoporphyrin derivative and 630 nm laser light). Proton im...

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Detalles Bibliográficos
Autores principales: Dodd, N. J., Moore, J. V., Poppitt, D. G., Wood, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247027/
https://www.ncbi.nlm.nih.gov/pubmed/2765361
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author Dodd, N. J.
Moore, J. V.
Poppitt, D. G.
Wood, B.
author_facet Dodd, N. J.
Moore, J. V.
Poppitt, D. G.
Wood, B.
author_sort Dodd, N. J.
collection PubMed
description Nuclear magnetic resonance (NMR) proton imaging and measurements of the parameters T1 and T2, have been carried out in vivo on the murine mammary tumour T50/80. Tumours had been treated 24 h previously by photodynamic therapy (PDT, using haematoporphyrin derivative and 630 nm laser light). Proton images clearly demarcated a high signal-intensity region on the side of the tumour closest to the incident light beam, while the parts of the tumour more remote from the beam resembled the images from untreated controls. Both T1 and T2 values were raised in the high-intensity region. This high-intensity region was shown to correspond to PDT-induced histological necrosis, the low-intensity region to histologically intact tumour. Linear regression analysis of the relationship of depth of necrosis measured histologically and 'depth of necrosis' measured from the NMR images, yielded a slope of 0.93 (r2 = 0.95). IMAGES:
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spelling pubmed-22470272009-09-10 In vivo magnetic resonance imaging of the effects of photodynamic therapy. Dodd, N. J. Moore, J. V. Poppitt, D. G. Wood, B. Br J Cancer Research Article Nuclear magnetic resonance (NMR) proton imaging and measurements of the parameters T1 and T2, have been carried out in vivo on the murine mammary tumour T50/80. Tumours had been treated 24 h previously by photodynamic therapy (PDT, using haematoporphyrin derivative and 630 nm laser light). Proton images clearly demarcated a high signal-intensity region on the side of the tumour closest to the incident light beam, while the parts of the tumour more remote from the beam resembled the images from untreated controls. Both T1 and T2 values were raised in the high-intensity region. This high-intensity region was shown to correspond to PDT-induced histological necrosis, the low-intensity region to histologically intact tumour. Linear regression analysis of the relationship of depth of necrosis measured histologically and 'depth of necrosis' measured from the NMR images, yielded a slope of 0.93 (r2 = 0.95). IMAGES: Nature Publishing Group 1989-08 /pmc/articles/PMC2247027/ /pubmed/2765361 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Dodd, N. J.
Moore, J. V.
Poppitt, D. G.
Wood, B.
In vivo magnetic resonance imaging of the effects of photodynamic therapy.
title In vivo magnetic resonance imaging of the effects of photodynamic therapy.
title_full In vivo magnetic resonance imaging of the effects of photodynamic therapy.
title_fullStr In vivo magnetic resonance imaging of the effects of photodynamic therapy.
title_full_unstemmed In vivo magnetic resonance imaging of the effects of photodynamic therapy.
title_short In vivo magnetic resonance imaging of the effects of photodynamic therapy.
title_sort in vivo magnetic resonance imaging of the effects of photodynamic therapy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247027/
https://www.ncbi.nlm.nih.gov/pubmed/2765361
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