Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish.

Epidemiological evidence has implicated Chinese salted fish as a human nasopharyngeal carcinogen. In the present study, 221 Wistar-Kyoto rats aged 21 days were randomly assigned to one of three experimental groups. Rats in group 1 (high dose group) were fed a powder diet of one part Chinese salted f...

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Autores principales: Yu, M. C., Nichols, P. W., Zou, X. N., Estes, J., Henderson, B. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247048/
https://www.ncbi.nlm.nih.gov/pubmed/2765365
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author Yu, M. C.
Nichols, P. W.
Zou, X. N.
Estes, J.
Henderson, B. E.
author_facet Yu, M. C.
Nichols, P. W.
Zou, X. N.
Estes, J.
Henderson, B. E.
author_sort Yu, M. C.
collection PubMed
description Epidemiological evidence has implicated Chinese salted fish as a human nasopharyngeal carcinogen. In the present study, 221 Wistar-Kyoto rats aged 21 days were randomly assigned to one of three experimental groups. Rats in group 1 (high dose group) were fed a powder diet of one part Chinese salted fish to three parts certified rat chow during the first 18 months. Similarly, rats in group 2 (low dose group) were fed a powder diet of one part salted fish to five parts rat chow for 18 months. Rats in group 3 were given rat chow only throughout the 3-year experiment. Four malignant tumours of the nasal cavity were observed among rats fed the experimental diets (three and one respectively in the high and low dose groups). No comparable tumours were observed in controls, compatible with the historical control rate of zero. Our results, therefore, further strengthen the hypothesis that Chinese salted fish is a human nasopharyngeal carcinogen; they also establish Wistar rats as a viable animal model for carcinogenicity studies of this food in the laboratory. IMAGES:
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spelling pubmed-22470482009-09-10 Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish. Yu, M. C. Nichols, P. W. Zou, X. N. Estes, J. Henderson, B. E. Br J Cancer Research Article Epidemiological evidence has implicated Chinese salted fish as a human nasopharyngeal carcinogen. In the present study, 221 Wistar-Kyoto rats aged 21 days were randomly assigned to one of three experimental groups. Rats in group 1 (high dose group) were fed a powder diet of one part Chinese salted fish to three parts certified rat chow during the first 18 months. Similarly, rats in group 2 (low dose group) were fed a powder diet of one part salted fish to five parts rat chow for 18 months. Rats in group 3 were given rat chow only throughout the 3-year experiment. Four malignant tumours of the nasal cavity were observed among rats fed the experimental diets (three and one respectively in the high and low dose groups). No comparable tumours were observed in controls, compatible with the historical control rate of zero. Our results, therefore, further strengthen the hypothesis that Chinese salted fish is a human nasopharyngeal carcinogen; they also establish Wistar rats as a viable animal model for carcinogenicity studies of this food in the laboratory. IMAGES: Nature Publishing Group 1989-08 /pmc/articles/PMC2247048/ /pubmed/2765365 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Yu, M. C.
Nichols, P. W.
Zou, X. N.
Estes, J.
Henderson, B. E.
Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish.
title Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish.
title_full Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish.
title_fullStr Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish.
title_full_unstemmed Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish.
title_short Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish.
title_sort induction of malignant nasal cavity tumours in wistar rats fed chinese salted fish.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247048/
https://www.ncbi.nlm.nih.gov/pubmed/2765365
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