The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.

Eighty-two patients were randomly allocated to receive intravenous acyclovir 5 mg kg-1 t.d.s. for 23 days followed by oral acyclovir 800 mg 6-hourly for 6 months or matching placebos after allogeneic bone marrow transplantation. Herpes simplex and varicella zoster virus infections were significantly...

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Autores principales: Selby, P. J., Powles, R. L., Easton, D., Perren, T. J., Stolle, K., Jameson, B., Fiddian, A. P., Tryhorn, Y., Stern, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247066/
https://www.ncbi.nlm.nih.gov/pubmed/2539180
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author Selby, P. J.
Powles, R. L.
Easton, D.
Perren, T. J.
Stolle, K.
Jameson, B.
Fiddian, A. P.
Tryhorn, Y.
Stern, H.
author_facet Selby, P. J.
Powles, R. L.
Easton, D.
Perren, T. J.
Stolle, K.
Jameson, B.
Fiddian, A. P.
Tryhorn, Y.
Stern, H.
author_sort Selby, P. J.
collection PubMed
description Eighty-two patients were randomly allocated to receive intravenous acyclovir 5 mg kg-1 t.d.s. for 23 days followed by oral acyclovir 800 mg 6-hourly for 6 months or matching placebos after allogeneic bone marrow transplantation. Herpes simplex and varicella zoster virus infections were significantly reduced during the period of administration of acyclovir. No reduction in cytomegalovirus infection was demonstrated. The drug was not toxic.
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spelling pubmed-22470662009-09-10 The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation. Selby, P. J. Powles, R. L. Easton, D. Perren, T. J. Stolle, K. Jameson, B. Fiddian, A. P. Tryhorn, Y. Stern, H. Br J Cancer Research Article Eighty-two patients were randomly allocated to receive intravenous acyclovir 5 mg kg-1 t.d.s. for 23 days followed by oral acyclovir 800 mg 6-hourly for 6 months or matching placebos after allogeneic bone marrow transplantation. Herpes simplex and varicella zoster virus infections were significantly reduced during the period of administration of acyclovir. No reduction in cytomegalovirus infection was demonstrated. The drug was not toxic. Nature Publishing Group 1989-03 /pmc/articles/PMC2247066/ /pubmed/2539180 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Selby, P. J.
Powles, R. L.
Easton, D.
Perren, T. J.
Stolle, K.
Jameson, B.
Fiddian, A. P.
Tryhorn, Y.
Stern, H.
The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.
title The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.
title_full The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.
title_fullStr The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.
title_full_unstemmed The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.
title_short The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.
title_sort prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247066/
https://www.ncbi.nlm.nih.gov/pubmed/2539180
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