Human non-Hodgkin's malignant lymphomas serially transplanted in nude mice conditioned with whole-body irradiation.

Direct transplantation of non-Hodgkin's malignant lymphoma into athymic nude mice was successfully achieved after whole-body irradiation (5 Gy). Twenty-seven per cent (6/22) of transplanted lymphomas were established as nude mouse lines. The successful lines were derived solely from the patient...

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Autores principales: Igarashi, T., Oka, K., Miyamoto, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247067/
https://www.ncbi.nlm.nih.gov/pubmed/2649134
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author Igarashi, T.
Oka, K.
Miyamoto, T.
author_facet Igarashi, T.
Oka, K.
Miyamoto, T.
author_sort Igarashi, T.
collection PubMed
description Direct transplantation of non-Hodgkin's malignant lymphoma into athymic nude mice was successfully achieved after whole-body irradiation (5 Gy). Twenty-seven per cent (6/22) of transplanted lymphomas were established as nude mouse lines. The successful lines were derived solely from the patients with diffuse lymphoma who showed advanced clinical stage, high LDH value, large mass and poor prognosis. The histological, immunophenotypic and chromosomal characteristics of the nude mouse lines were compared with those of the original lymphomas, and the proliferative characteristics of the lines were examined. The transplanted lymphomas substantially retained the characteristics of the original lymphomas, and could be useful in biological, oncological and therapeutic studies of human malignant lymphoma. IMAGES:
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spelling pubmed-22470672009-09-10 Human non-Hodgkin's malignant lymphomas serially transplanted in nude mice conditioned with whole-body irradiation. Igarashi, T. Oka, K. Miyamoto, T. Br J Cancer Research Article Direct transplantation of non-Hodgkin's malignant lymphoma into athymic nude mice was successfully achieved after whole-body irradiation (5 Gy). Twenty-seven per cent (6/22) of transplanted lymphomas were established as nude mouse lines. The successful lines were derived solely from the patients with diffuse lymphoma who showed advanced clinical stage, high LDH value, large mass and poor prognosis. The histological, immunophenotypic and chromosomal characteristics of the nude mouse lines were compared with those of the original lymphomas, and the proliferative characteristics of the lines were examined. The transplanted lymphomas substantially retained the characteristics of the original lymphomas, and could be useful in biological, oncological and therapeutic studies of human malignant lymphoma. IMAGES: Nature Publishing Group 1989-03 /pmc/articles/PMC2247067/ /pubmed/2649134 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Igarashi, T.
Oka, K.
Miyamoto, T.
Human non-Hodgkin's malignant lymphomas serially transplanted in nude mice conditioned with whole-body irradiation.
title Human non-Hodgkin's malignant lymphomas serially transplanted in nude mice conditioned with whole-body irradiation.
title_full Human non-Hodgkin's malignant lymphomas serially transplanted in nude mice conditioned with whole-body irradiation.
title_fullStr Human non-Hodgkin's malignant lymphomas serially transplanted in nude mice conditioned with whole-body irradiation.
title_full_unstemmed Human non-Hodgkin's malignant lymphomas serially transplanted in nude mice conditioned with whole-body irradiation.
title_short Human non-Hodgkin's malignant lymphomas serially transplanted in nude mice conditioned with whole-body irradiation.
title_sort human non-hodgkin's malignant lymphomas serially transplanted in nude mice conditioned with whole-body irradiation.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247067/
https://www.ncbi.nlm.nih.gov/pubmed/2649134
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AT miyamotot humannonhodgkinsmalignantlymphomasseriallytransplantedinnudemiceconditionedwithwholebodyirradiation

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