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Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes.

One hundred and seventy-one cases of operable invasive lobular carcinoma, presenting over an 11-year period, were reviewed. Histological subtypes were investigated to determine differences in their clinical behaviour and whether these differences could be explained by histopathological features. Fiv...

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Autores principales: du Toit, R. S., Locker, A. P., Ellis, I. O., Elston, C. W., Nicholson, R. I., Blamey, R. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247102/
https://www.ncbi.nlm.nih.gov/pubmed/2803932
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author du Toit, R. S.
Locker, A. P.
Ellis, I. O.
Elston, C. W.
Nicholson, R. I.
Blamey, R. W.
author_facet du Toit, R. S.
Locker, A. P.
Ellis, I. O.
Elston, C. W.
Nicholson, R. I.
Blamey, R. W.
author_sort du Toit, R. S.
collection PubMed
description One hundred and seventy-one cases of operable invasive lobular carcinoma, presenting over an 11-year period, were reviewed. Histological subtypes were investigated to determine differences in their clinical behaviour and whether these differences could be explained by histopathological features. Five subtypes were identified: mixed (45.6%), classical (30.4%), tubulo-lobular (13.5%), solid (6.4%) and alveolar (4.1%). The median follow-up period was 64 months and the median age 54 years. The 12-year actuarial survival rate was 100% for the tubulo-lobular subtype, but only 47% for the solid variant. Similar differences were found in the disease free interval, locoregional and distant metastatic rates between these two subtypes. The tubulo-lobular tumours were more likely to be of good histological grade and node negative. The other three subtypes did not differ significantly in their histopathological parameters, reflected in similar clinical behaviour. They occupied an intermediate position between the other two subtypes in terms of prognosis.
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spelling pubmed-22471022009-09-10 Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes. du Toit, R. S. Locker, A. P. Ellis, I. O. Elston, C. W. Nicholson, R. I. Blamey, R. W. Br J Cancer Research Article One hundred and seventy-one cases of operable invasive lobular carcinoma, presenting over an 11-year period, were reviewed. Histological subtypes were investigated to determine differences in their clinical behaviour and whether these differences could be explained by histopathological features. Five subtypes were identified: mixed (45.6%), classical (30.4%), tubulo-lobular (13.5%), solid (6.4%) and alveolar (4.1%). The median follow-up period was 64 months and the median age 54 years. The 12-year actuarial survival rate was 100% for the tubulo-lobular subtype, but only 47% for the solid variant. Similar differences were found in the disease free interval, locoregional and distant metastatic rates between these two subtypes. The tubulo-lobular tumours were more likely to be of good histological grade and node negative. The other three subtypes did not differ significantly in their histopathological parameters, reflected in similar clinical behaviour. They occupied an intermediate position between the other two subtypes in terms of prognosis. Nature Publishing Group 1989-10 /pmc/articles/PMC2247102/ /pubmed/2803932 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
du Toit, R. S.
Locker, A. P.
Ellis, I. O.
Elston, C. W.
Nicholson, R. I.
Blamey, R. W.
Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes.
title Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes.
title_full Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes.
title_fullStr Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes.
title_full_unstemmed Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes.
title_short Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes.
title_sort invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247102/
https://www.ncbi.nlm.nih.gov/pubmed/2803932
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