No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer.

To study the possible involvement of mouse mammary tumour virus (MMTV) related agent in human cancer we analysed 300 samples of human sera for the presence of antibodies to MMTV structural proteins. All sera were tested by immunoblotting to achieve high specificity. Out of 300 sera, 22 reacted with...

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Autores principales: Kovarík, A., Hlubinová, K., Prachar, J., Simkovic, D., Knotek, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247107/
https://www.ncbi.nlm.nih.gov/pubmed/2553093
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author Kovarík, A.
Hlubinová, K.
Prachar, J.
Simkovic, D.
Knotek, J.
author_facet Kovarík, A.
Hlubinová, K.
Prachar, J.
Simkovic, D.
Knotek, J.
author_sort Kovarík, A.
collection PubMed
description To study the possible involvement of mouse mammary tumour virus (MMTV) related agent in human cancer we analysed 300 samples of human sera for the presence of antibodies to MMTV structural proteins. All sera were tested by immunoblotting to achieve high specificity. Out of 300 sera, 22 reacted with transframe protein p30, 16 with the ribonucleoprotein p14, six with the envelope glycoprotein gp52 and three with the major core protein p27. Reactivities to p30 and p14 were observed in sera from cancer patients and healthy controls; reactivities to p27 and gp52 predominated in sera of cancer patients. Sera frequently reacted with a 42 kDa protein which is a cellular contaminant of the virus. IMAGES:
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spelling pubmed-22471072009-09-10 No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer. Kovarík, A. Hlubinová, K. Prachar, J. Simkovic, D. Knotek, J. Br J Cancer Research Article To study the possible involvement of mouse mammary tumour virus (MMTV) related agent in human cancer we analysed 300 samples of human sera for the presence of antibodies to MMTV structural proteins. All sera were tested by immunoblotting to achieve high specificity. Out of 300 sera, 22 reacted with transframe protein p30, 16 with the ribonucleoprotein p14, six with the envelope glycoprotein gp52 and three with the major core protein p27. Reactivities to p30 and p14 were observed in sera from cancer patients and healthy controls; reactivities to p27 and gp52 predominated in sera of cancer patients. Sera frequently reacted with a 42 kDa protein which is a cellular contaminant of the virus. IMAGES: Nature Publishing Group 1989-10 /pmc/articles/PMC2247107/ /pubmed/2553093 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kovarík, A.
Hlubinová, K.
Prachar, J.
Simkovic, D.
Knotek, J.
No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer.
title No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer.
title_full No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer.
title_fullStr No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer.
title_full_unstemmed No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer.
title_short No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer.
title_sort no significant correlation between specific antibodies to mouse mammary tumour virus and human cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247107/
https://www.ncbi.nlm.nih.gov/pubmed/2553093
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