Genetic and immunopathological findings in a lymphoma family.

We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin's lymphoma, while a granddaughter had Hodgkin's disease. An immunological study of three lymph...

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Autores principales: Lynch, H. T., Marcus, J. N., Weisenburger, D. D., Watson, P., Fitzsimmons, M. L., Grierson, H., Smith, D. M., Lynch, J., Purtilo, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247145/
https://www.ncbi.nlm.nih.gov/pubmed/2713249
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author Lynch, H. T.
Marcus, J. N.
Weisenburger, D. D.
Watson, P.
Fitzsimmons, M. L.
Grierson, H.
Smith, D. M.
Lynch, J.
Purtilo, D.
author_facet Lynch, H. T.
Marcus, J. N.
Weisenburger, D. D.
Watson, P.
Fitzsimmons, M. L.
Grierson, H.
Smith, D. M.
Lynch, J.
Purtilo, D.
author_sort Lynch, H. T.
collection PubMed
description We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin's lymphoma, while a granddaughter had Hodgkin's disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3 level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.
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spelling pubmed-22471452009-09-10 Genetic and immunopathological findings in a lymphoma family. Lynch, H. T. Marcus, J. N. Weisenburger, D. D. Watson, P. Fitzsimmons, M. L. Grierson, H. Smith, D. M. Lynch, J. Purtilo, D. Br J Cancer Research Article We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin's lymphoma, while a granddaughter had Hodgkin's disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3 level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas. Nature Publishing Group 1989-04 /pmc/articles/PMC2247145/ /pubmed/2713249 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Lynch, H. T.
Marcus, J. N.
Weisenburger, D. D.
Watson, P.
Fitzsimmons, M. L.
Grierson, H.
Smith, D. M.
Lynch, J.
Purtilo, D.
Genetic and immunopathological findings in a lymphoma family.
title Genetic and immunopathological findings in a lymphoma family.
title_full Genetic and immunopathological findings in a lymphoma family.
title_fullStr Genetic and immunopathological findings in a lymphoma family.
title_full_unstemmed Genetic and immunopathological findings in a lymphoma family.
title_short Genetic and immunopathological findings in a lymphoma family.
title_sort genetic and immunopathological findings in a lymphoma family.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247145/
https://www.ncbi.nlm.nih.gov/pubmed/2713249
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