An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.

Attempts have been made by a number of methods to eliminate minimal residual disease from bone marrow to be reinfused in autologous transplantation. In this paper we describe a conjugate containing a monoclonal antibody, named 8A, recognising a plasma cell-associated antigen, and momordin, a ribosom...

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Autores principales: Dinota, A., Barbieri, L., Gobbi, M., Tazzari, P. L., Rizzi, S., Bontadini, A., Bolognesi, A., Tura, S., Stirpe, F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247190/
https://www.ncbi.nlm.nih.gov/pubmed/2789938
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author Dinota, A.
Barbieri, L.
Gobbi, M.
Tazzari, P. L.
Rizzi, S.
Bontadini, A.
Bolognesi, A.
Tura, S.
Stirpe, F.
author_facet Dinota, A.
Barbieri, L.
Gobbi, M.
Tazzari, P. L.
Rizzi, S.
Bontadini, A.
Bolognesi, A.
Tura, S.
Stirpe, F.
author_sort Dinota, A.
collection PubMed
description Attempts have been made by a number of methods to eliminate minimal residual disease from bone marrow to be reinfused in autologous transplantation. In this paper we describe a conjugate containing a monoclonal antibody, named 8A, recognising a plasma cell-associated antigen, and momordin, a ribosome-inactivating protein similar to the ricin A-chain. This immunotoxin is active on target cell lines and on neoplastic plasma cells, while myeloid progenitors are fairly resistant. The conjugate is shown to be acceptable for ex vivo purging in autologous bone marrow transplantation in multiple myeloma patients.
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spelling pubmed-22471902009-09-10 An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients. Dinota, A. Barbieri, L. Gobbi, M. Tazzari, P. L. Rizzi, S. Bontadini, A. Bolognesi, A. Tura, S. Stirpe, F. Br J Cancer Research Article Attempts have been made by a number of methods to eliminate minimal residual disease from bone marrow to be reinfused in autologous transplantation. In this paper we describe a conjugate containing a monoclonal antibody, named 8A, recognising a plasma cell-associated antigen, and momordin, a ribosome-inactivating protein similar to the ricin A-chain. This immunotoxin is active on target cell lines and on neoplastic plasma cells, while myeloid progenitors are fairly resistant. The conjugate is shown to be acceptable for ex vivo purging in autologous bone marrow transplantation in multiple myeloma patients. Nature Publishing Group 1989-09 /pmc/articles/PMC2247190/ /pubmed/2789938 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Dinota, A.
Barbieri, L.
Gobbi, M.
Tazzari, P. L.
Rizzi, S.
Bontadini, A.
Bolognesi, A.
Tura, S.
Stirpe, F.
An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.
title An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.
title_full An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.
title_fullStr An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.
title_full_unstemmed An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.
title_short An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.
title_sort immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247190/
https://www.ncbi.nlm.nih.gov/pubmed/2789938
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