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Hydroethidine: a fluorescent redox probe for locating hypoxic cells in spheroids and murine tumours.
The fluorescent redox probe hydroethidine was accumulated and metabolised about five times faster in aerobic than in hypoxic mammalian cells. Patterns of fluorescence in Chinese hamster V79 spheroids also indicated that internal hypoxic cells were less able to metabolise the drug; toxicity was obser...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
1989
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247196/ https://www.ncbi.nlm.nih.gov/pubmed/2789941 |