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Maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial.

In a prospective randomised study 68 patients with limited small cell bronchogenic carcinoma were assigned to induction treatment with combined alternating non-cross-resistant chemotherapy plus split course radiotherapy without (NM) or with (M) subsequent maintenance therapy. Induction chemotherapy...

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Autores principales: Byrne, M. J., van Hazel, G., Trotter, J., Cameron, F., Shepherd, J., Cassidy, B., Gebski, V.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247200/
https://www.ncbi.nlm.nih.gov/pubmed/2551359
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author Byrne, M. J.
van Hazel, G.
Trotter, J.
Cameron, F.
Shepherd, J.
Cassidy, B.
Gebski, V.
author_facet Byrne, M. J.
van Hazel, G.
Trotter, J.
Cameron, F.
Shepherd, J.
Cassidy, B.
Gebski, V.
author_sort Byrne, M. J.
collection PubMed
description In a prospective randomised study 68 patients with limited small cell bronchogenic carcinoma were assigned to induction treatment with combined alternating non-cross-resistant chemotherapy plus split course radiotherapy without (NM) or with (M) subsequent maintenance therapy. Induction chemotherapy consisted of cisplatinum and VP16213q. 3 weeks followed by cyclophosphamide, vincristine and methotrexate (CVM)q. 4 weeks. Three courses of this 7-week chemotherapy programme were given. Radiotherapy to the primary lesion of 25 Gy in 13 fractions was given after each of the first and second courses of chemotherapy. Those in complete remission following the induction phase received prophylactic cranial irradiation. Those assigned to maintenance received a further six cycles of CVM after induction. The overall survival of patients randomised to maintenance therapy was significantly inferior to that of those randomised to no maintenance therapy (median survival NM 19.2 vs M 14.1 months, P = 0.05 log rank). Among patients achieving a complete remission of disease on induction therapy those receiving maintenance also showed a trend towards inferior survival (median survival NM 26.8 vs 18.0 months, P = 0.06 log rank). Deaths in each group of patients were predominantly due to tumour progression. The results do not support the use of maintenance chemotherapy after the use of intensive combined therapy induction programmes in the management of limited small cell bronchogenic carcinoma.
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spelling pubmed-22472002009-09-10 Maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial. Byrne, M. J. van Hazel, G. Trotter, J. Cameron, F. Shepherd, J. Cassidy, B. Gebski, V. Br J Cancer Research Article In a prospective randomised study 68 patients with limited small cell bronchogenic carcinoma were assigned to induction treatment with combined alternating non-cross-resistant chemotherapy plus split course radiotherapy without (NM) or with (M) subsequent maintenance therapy. Induction chemotherapy consisted of cisplatinum and VP16213q. 3 weeks followed by cyclophosphamide, vincristine and methotrexate (CVM)q. 4 weeks. Three courses of this 7-week chemotherapy programme were given. Radiotherapy to the primary lesion of 25 Gy in 13 fractions was given after each of the first and second courses of chemotherapy. Those in complete remission following the induction phase received prophylactic cranial irradiation. Those assigned to maintenance received a further six cycles of CVM after induction. The overall survival of patients randomised to maintenance therapy was significantly inferior to that of those randomised to no maintenance therapy (median survival NM 19.2 vs M 14.1 months, P = 0.05 log rank). Among patients achieving a complete remission of disease on induction therapy those receiving maintenance also showed a trend towards inferior survival (median survival NM 26.8 vs 18.0 months, P = 0.06 log rank). Deaths in each group of patients were predominantly due to tumour progression. The results do not support the use of maintenance chemotherapy after the use of intensive combined therapy induction programmes in the management of limited small cell bronchogenic carcinoma. Nature Publishing Group 1989-09 /pmc/articles/PMC2247200/ /pubmed/2551359 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Byrne, M. J.
van Hazel, G.
Trotter, J.
Cameron, F.
Shepherd, J.
Cassidy, B.
Gebski, V.
Maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial.
title Maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial.
title_full Maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial.
title_fullStr Maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial.
title_full_unstemmed Maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial.
title_short Maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial.
title_sort maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247200/
https://www.ncbi.nlm.nih.gov/pubmed/2551359
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