Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres.

A comparison of the cytotoxic effectiveness of adriamycin incorporated into ion exchange microspheres with conventional chemotherapeutic use of adriamycin was carried out in a rat tumour model. Drug microspheres were targeted to the tumours by embolisation into the arterial supply of the hind limb b...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, C., Burton, M. A., Gray, B. N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247224/
https://www.ncbi.nlm.nih.gov/pubmed/2736208
_version_ 1782150936035065856
author Jones, C.
Burton, M. A.
Gray, B. N.
author_facet Jones, C.
Burton, M. A.
Gray, B. N.
author_sort Jones, C.
collection PubMed
description A comparison of the cytotoxic effectiveness of adriamycin incorporated into ion exchange microspheres with conventional chemotherapeutic use of adriamycin was carried out in a rat tumour model. Drug microspheres were targeted to the tumours by embolisation into the arterial supply of the hind limb bearing the tumour. Microspheres were found to embolise in tumour tissue at concentrations of up to 39 times that of the surrounding normal tissue. As a result, adriamycin microsphere therapy was found to retard significantly (P less than 0.01) tumour growth rates compared to growth rates associated with similar doses of adriamycin delivered as free drug rather than bound to controlled release microspheres. Equivalent sham microsphere treatments showed no significant difference in tumour growth rates compared with the control group. Adriamycin loaded on to ion exchange microspheres holds strong potential for treatment of human malignancy.
format Text
id pubmed-2247224
institution National Center for Biotechnology Information
language English
publishDate 1989
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-22472242009-09-10 Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres. Jones, C. Burton, M. A. Gray, B. N. Br J Cancer Research Article A comparison of the cytotoxic effectiveness of adriamycin incorporated into ion exchange microspheres with conventional chemotherapeutic use of adriamycin was carried out in a rat tumour model. Drug microspheres were targeted to the tumours by embolisation into the arterial supply of the hind limb bearing the tumour. Microspheres were found to embolise in tumour tissue at concentrations of up to 39 times that of the surrounding normal tissue. As a result, adriamycin microsphere therapy was found to retard significantly (P less than 0.01) tumour growth rates compared to growth rates associated with similar doses of adriamycin delivered as free drug rather than bound to controlled release microspheres. Equivalent sham microsphere treatments showed no significant difference in tumour growth rates compared with the control group. Adriamycin loaded on to ion exchange microspheres holds strong potential for treatment of human malignancy. Nature Publishing Group 1989-05 /pmc/articles/PMC2247224/ /pubmed/2736208 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Jones, C.
Burton, M. A.
Gray, B. N.
Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres.
title Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres.
title_full Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres.
title_fullStr Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres.
title_full_unstemmed Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres.
title_short Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres.
title_sort enhanced in vivo activity of adriamycin incorporated into controlled release microspheres.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247224/
https://www.ncbi.nlm.nih.gov/pubmed/2736208
work_keys_str_mv AT jonesc enhancedinvivoactivityofadriamycinincorporatedintocontrolledreleasemicrospheres
AT burtonma enhancedinvivoactivityofadriamycinincorporatedintocontrolledreleasemicrospheres
AT graybn enhancedinvivoactivityofadriamycinincorporatedintocontrolledreleasemicrospheres

Ejemplares similares