Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.

A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or...

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Autores principales: Burns, J. S., Lemoine, L., Lemoine, N. R., Williams, E. D., Wynford-Thomas, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247228/
https://www.ncbi.nlm.nih.gov/pubmed/2544221
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author Burns, J. S.
Lemoine, L.
Lemoine, N. R.
Williams, E. D.
Wynford-Thomas, D.
author_facet Burns, J. S.
Lemoine, L.
Lemoine, N. R.
Williams, E. D.
Wynford-Thomas, D.
author_sort Burns, J. S.
collection PubMed
description A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer. IMAGES:
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spelling pubmed-22472282009-09-10 Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T. Burns, J. S. Lemoine, L. Lemoine, N. R. Williams, E. D. Wynford-Thomas, D. Br J Cancer Research Article A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer. IMAGES: Nature Publishing Group 1989-05 /pmc/articles/PMC2247228/ /pubmed/2544221 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Burns, J. S.
Lemoine, L.
Lemoine, N. R.
Williams, E. D.
Wynford-Thomas, D.
Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.
title Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.
title_full Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.
title_fullStr Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.
title_full_unstemmed Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.
title_short Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.
title_sort thyroid epithelial cell transformation by a retroviral vector expressing sv40 large t.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247228/
https://www.ncbi.nlm.nih.gov/pubmed/2544221
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