Quantitative magnetic resonance imaging in autologous bone marrow transplantation for Hodgkin's disease.

Fifteen consecutive patients with refractory or relapsed Hodgkin's disease (HD) referred for autologous bone marrow transplantation (ABMT) underwent quantitative magnetic resonance (MR) studies of the lumbar vertebral bone marrow. Markedly elevated lumbar vertebral marrow T1 values suggestive o...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, S. R., Williams, C. E., Edwards, R. H., Davies, J. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247251/
https://www.ncbi.nlm.nih.gov/pubmed/2605106
_version_ 1782150941962665984
author Smith, S. R.
Williams, C. E.
Edwards, R. H.
Davies, J. M.
author_facet Smith, S. R.
Williams, C. E.
Edwards, R. H.
Davies, J. M.
author_sort Smith, S. R.
collection PubMed
description Fifteen consecutive patients with refractory or relapsed Hodgkin's disease (HD) referred for autologous bone marrow transplantation (ABMT) underwent quantitative magnetic resonance (MR) studies of the lumbar vertebral bone marrow. Markedly elevated lumbar vertebral marrow T1 values suggestive of bone marrow involvement with HD were seen in four patients, two of whom had no evidence of HD on bilateral iliac crest bone marrow biopsy. Serial studies showed normalisation of T1 values in the post-transplant period. T1 relaxation rate correlated positively with time to engraftment following ABMT and a significant correlation (r = 0.73, 0.02 greater than P greater than 0.01) between T2 relaxation rate and granulocyte and macrophage colony forming units (CFU-GM) of processed bone marrow was seen. This preliminary study illustrates the potential role of quantitative MRI both in the pre-transplant assessment of patients considered for ABMT and in the post-transplant evaluation of tumour response when marrow involvement with HD is present. IMAGES:
format Text
id pubmed-2247251
institution National Center for Biotechnology Information
language English
publishDate 1989
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-22472512009-09-10 Quantitative magnetic resonance imaging in autologous bone marrow transplantation for Hodgkin's disease. Smith, S. R. Williams, C. E. Edwards, R. H. Davies, J. M. Br J Cancer Research Article Fifteen consecutive patients with refractory or relapsed Hodgkin's disease (HD) referred for autologous bone marrow transplantation (ABMT) underwent quantitative magnetic resonance (MR) studies of the lumbar vertebral bone marrow. Markedly elevated lumbar vertebral marrow T1 values suggestive of bone marrow involvement with HD were seen in four patients, two of whom had no evidence of HD on bilateral iliac crest bone marrow biopsy. Serial studies showed normalisation of T1 values in the post-transplant period. T1 relaxation rate correlated positively with time to engraftment following ABMT and a significant correlation (r = 0.73, 0.02 greater than P greater than 0.01) between T2 relaxation rate and granulocyte and macrophage colony forming units (CFU-GM) of processed bone marrow was seen. This preliminary study illustrates the potential role of quantitative MRI both in the pre-transplant assessment of patients considered for ABMT and in the post-transplant evaluation of tumour response when marrow involvement with HD is present. IMAGES: Nature Publishing Group 1989-12 /pmc/articles/PMC2247251/ /pubmed/2605106 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Smith, S. R.
Williams, C. E.
Edwards, R. H.
Davies, J. M.
Quantitative magnetic resonance imaging in autologous bone marrow transplantation for Hodgkin's disease.
title Quantitative magnetic resonance imaging in autologous bone marrow transplantation for Hodgkin's disease.
title_full Quantitative magnetic resonance imaging in autologous bone marrow transplantation for Hodgkin's disease.
title_fullStr Quantitative magnetic resonance imaging in autologous bone marrow transplantation for Hodgkin's disease.
title_full_unstemmed Quantitative magnetic resonance imaging in autologous bone marrow transplantation for Hodgkin's disease.
title_short Quantitative magnetic resonance imaging in autologous bone marrow transplantation for Hodgkin's disease.
title_sort quantitative magnetic resonance imaging in autologous bone marrow transplantation for hodgkin's disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247251/
https://www.ncbi.nlm.nih.gov/pubmed/2605106
work_keys_str_mv AT smithsr quantitativemagneticresonanceimaginginautologousbonemarrowtransplantationforhodgkinsdisease
AT williamsce quantitativemagneticresonanceimaginginautologousbonemarrowtransplantationforhodgkinsdisease
AT edwardsrh quantitativemagneticresonanceimaginginautologousbonemarrowtransplantationforhodgkinsdisease
AT daviesjm quantitativemagneticresonanceimaginginautologousbonemarrowtransplantationforhodgkinsdisease

Ejemplares similares