P-glycoprotein expression in treated and untreated human breast cancer.

The expression of P-glycoprotein in primary and recurrent human breast cancer was investigated by means of immunohistochemistry, using a monoclonal antibody (C219) and the streptavidin-biotin-peroxidase method. Twelve patients received no chemotherapeutic treatment. The other 11 patients were treate...

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Autores principales: Schneider, J., Bak, M., Efferth, T., Kaufmann, M., Mattern, J., Volm, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247284/
https://www.ncbi.nlm.nih.gov/pubmed/2574987
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author Schneider, J.
Bak, M.
Efferth, T.
Kaufmann, M.
Mattern, J.
Volm, M.
author_facet Schneider, J.
Bak, M.
Efferth, T.
Kaufmann, M.
Mattern, J.
Volm, M.
author_sort Schneider, J.
collection PubMed
description The expression of P-glycoprotein in primary and recurrent human breast cancer was investigated by means of immunohistochemistry, using a monoclonal antibody (C219) and the streptavidin-biotin-peroxidase method. Twelve patients received no chemotherapeutic treatment. The other 11 patients were treated with chemotherapy, and all developed clinical resistance to it. No or only minimal reactivity was found in specimens coming from the untreated patients (12 cases) or from patients treated with substances not involved in the multidrug resistance phenomenon (four cases). In contrast, three out of seven tumours from patients treated with multidrug resistance related substances showed clear reactivity (positive staining in more than 20% of the tumour cells). In one of these cases, where specimens of the tumour could be studied before and after treatment, an association between the latter and expression of P-glycoprotein was suggested. Finally, this marked expression of P-glycoprotein only took place in tumours treated over a longer space of time (five courses or more of multidrug resistance related chemotherapy). IMAGES:
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spelling pubmed-22472842009-09-10 P-glycoprotein expression in treated and untreated human breast cancer. Schneider, J. Bak, M. Efferth, T. Kaufmann, M. Mattern, J. Volm, M. Br J Cancer Research Article The expression of P-glycoprotein in primary and recurrent human breast cancer was investigated by means of immunohistochemistry, using a monoclonal antibody (C219) and the streptavidin-biotin-peroxidase method. Twelve patients received no chemotherapeutic treatment. The other 11 patients were treated with chemotherapy, and all developed clinical resistance to it. No or only minimal reactivity was found in specimens coming from the untreated patients (12 cases) or from patients treated with substances not involved in the multidrug resistance phenomenon (four cases). In contrast, three out of seven tumours from patients treated with multidrug resistance related substances showed clear reactivity (positive staining in more than 20% of the tumour cells). In one of these cases, where specimens of the tumour could be studied before and after treatment, an association between the latter and expression of P-glycoprotein was suggested. Finally, this marked expression of P-glycoprotein only took place in tumours treated over a longer space of time (five courses or more of multidrug resistance related chemotherapy). IMAGES: Nature Publishing Group 1989-12 /pmc/articles/PMC2247284/ /pubmed/2574987 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Schneider, J.
Bak, M.
Efferth, T.
Kaufmann, M.
Mattern, J.
Volm, M.
P-glycoprotein expression in treated and untreated human breast cancer.
title P-glycoprotein expression in treated and untreated human breast cancer.
title_full P-glycoprotein expression in treated and untreated human breast cancer.
title_fullStr P-glycoprotein expression in treated and untreated human breast cancer.
title_full_unstemmed P-glycoprotein expression in treated and untreated human breast cancer.
title_short P-glycoprotein expression in treated and untreated human breast cancer.
title_sort p-glycoprotein expression in treated and untreated human breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247284/
https://www.ncbi.nlm.nih.gov/pubmed/2574987
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