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Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa.
Acid soluble proteins from 23 samples of normal human gastrointestinal mucosa derived from four normal adult organ donors were extracted and subjected to specific radiommunoassays for transforming growth factor alpha (TGF alpha) and urogastrone epidermal growth factor (URO-EGF). All tissues were fou...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1989
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247287/ https://www.ncbi.nlm.nih.gov/pubmed/2803941 |
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author | Cartlidge, S. A. Elder, J. B. |
author_facet | Cartlidge, S. A. Elder, J. B. |
author_sort | Cartlidge, S. A. |
collection | PubMed |
description | Acid soluble proteins from 23 samples of normal human gastrointestinal mucosa derived from four normal adult organ donors were extracted and subjected to specific radiommunoassays for transforming growth factor alpha (TGF alpha) and urogastrone epidermal growth factor (URO-EGF). All tissues were found to contain immunoreactive TGF alpha and levels ranged from 57 to 4,776 pg-1 wet weight of tissue. Although levels varied between tissue donors, the distribution of TGF alpha throughout the gastrointestinal tract appeared similar in all cases. URO-EGF levels were much lower (0-216 pg g-1 wet weight). TGF alpha levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels. URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient. Further studies in juveniles are indicated. |
format | Text |
id | pubmed-2247287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1989 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-22472872009-09-10 Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa. Cartlidge, S. A. Elder, J. B. Br J Cancer Research Article Acid soluble proteins from 23 samples of normal human gastrointestinal mucosa derived from four normal adult organ donors were extracted and subjected to specific radiommunoassays for transforming growth factor alpha (TGF alpha) and urogastrone epidermal growth factor (URO-EGF). All tissues were found to contain immunoreactive TGF alpha and levels ranged from 57 to 4,776 pg-1 wet weight of tissue. Although levels varied between tissue donors, the distribution of TGF alpha throughout the gastrointestinal tract appeared similar in all cases. URO-EGF levels were much lower (0-216 pg g-1 wet weight). TGF alpha levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels. URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient. Further studies in juveniles are indicated. Nature Publishing Group 1989-11 /pmc/articles/PMC2247287/ /pubmed/2803941 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Cartlidge, S. A. Elder, J. B. Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa. |
title | Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa. |
title_full | Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa. |
title_fullStr | Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa. |
title_full_unstemmed | Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa. |
title_short | Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa. |
title_sort | transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247287/ https://www.ncbi.nlm.nih.gov/pubmed/2803941 |
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