Cargando…

Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats.

Iron appears to play a major role in catalysing free radical production, leading to lipid peroxidation and DNA damage. We, therefore, investigated the effect of colloidal iron deposited in the peritoneum. Wistar male rats were given either ferric saccharate, ferric saccharate and nitrilotriacetic ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Okada, S., Hamazaki, S., Toyokuni, S., Midorikawa, O.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247310/
https://www.ncbi.nlm.nih.gov/pubmed/2803947
_version_ 1782150954548723712
author Okada, S.
Hamazaki, S.
Toyokuni, S.
Midorikawa, O.
author_facet Okada, S.
Hamazaki, S.
Toyokuni, S.
Midorikawa, O.
author_sort Okada, S.
collection PubMed
description Iron appears to play a major role in catalysing free radical production, leading to lipid peroxidation and DNA damage. We, therefore, investigated the effect of colloidal iron deposited in the peritoneum. Wistar male rats were given either ferric saccharate, ferric saccharate and nitrilotriacetic acid (NTA), NTA or saline. NTA was shown previously to 'free' iron to promote lipid peroxidation and an iron chelate of NTA is known to be carcinogenic to the kidney. Iron at a dose of 5 mg kg-1 day-1, and saline at a dose of 0.5 ml day-1 were injected i.p. for 3 months. NTA at a dose of 83.5 mg kg-1 day-1 was give i.p. for 5 months. All the rats were killed about a year later for histological examination. In nine of the 19 rats treated with ferric saccharate, mesothelial tumors were induced in the serosa of the tunica vaginalis or the length of the spermatic cord. Among rats treated with ferric saccharate and NTA, seven had localised mesotheliomas in the above locations and six had wide-spread peritoneal mesotheliomas. No mesothelial tumors developed in either NTA treated or saline treated rats. No pleural mesotheliomas were found in any group. These findings add to the evidence that iron is involved in some carcinogenic processes. IMAGES:
format Text
id pubmed-2247310
institution National Center for Biotechnology Information
language English
publishDate 1989
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-22473102009-09-10 Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats. Okada, S. Hamazaki, S. Toyokuni, S. Midorikawa, O. Br J Cancer Research Article Iron appears to play a major role in catalysing free radical production, leading to lipid peroxidation and DNA damage. We, therefore, investigated the effect of colloidal iron deposited in the peritoneum. Wistar male rats were given either ferric saccharate, ferric saccharate and nitrilotriacetic acid (NTA), NTA or saline. NTA was shown previously to 'free' iron to promote lipid peroxidation and an iron chelate of NTA is known to be carcinogenic to the kidney. Iron at a dose of 5 mg kg-1 day-1, and saline at a dose of 0.5 ml day-1 were injected i.p. for 3 months. NTA at a dose of 83.5 mg kg-1 day-1 was give i.p. for 5 months. All the rats were killed about a year later for histological examination. In nine of the 19 rats treated with ferric saccharate, mesothelial tumors were induced in the serosa of the tunica vaginalis or the length of the spermatic cord. Among rats treated with ferric saccharate and NTA, seven had localised mesotheliomas in the above locations and six had wide-spread peritoneal mesotheliomas. No mesothelial tumors developed in either NTA treated or saline treated rats. No pleural mesotheliomas were found in any group. These findings add to the evidence that iron is involved in some carcinogenic processes. IMAGES: Nature Publishing Group 1989-11 /pmc/articles/PMC2247310/ /pubmed/2803947 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Okada, S.
Hamazaki, S.
Toyokuni, S.
Midorikawa, O.
Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats.
title Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats.
title_full Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats.
title_fullStr Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats.
title_full_unstemmed Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats.
title_short Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats.
title_sort induction of mesothelioma by intraperitoneal injections of ferric saccharate in male wistar rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247310/
https://www.ncbi.nlm.nih.gov/pubmed/2803947
work_keys_str_mv AT okadas inductionofmesotheliomabyintraperitonealinjectionsofferricsaccharateinmalewistarrats
AT hamazakis inductionofmesotheliomabyintraperitonealinjectionsofferricsaccharateinmalewistarrats
AT toyokunis inductionofmesotheliomabyintraperitonealinjectionsofferricsaccharateinmalewistarrats
AT midorikawao inductionofmesotheliomabyintraperitonealinjectionsofferricsaccharateinmalewistarrats