Polyclonal origin of mouse skin papillomas.

We show that, from the earliest morphologically recognisable stages of development, mouse skin papillomas induced by a chemical initiation-promotion regime are polyclonal. We have demonstrated polyclonality directly by immunohistochemical staining of the mosaic cell populations in embryo aggregation...

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Detalles Bibliográficos
Autores principales: Winton, D. J., Blount, M. A., Ponder, B. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247333/
https://www.ncbi.nlm.nih.gov/pubmed/2803917
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author Winton, D. J.
Blount, M. A.
Ponder, B. A.
author_facet Winton, D. J.
Blount, M. A.
Ponder, B. A.
author_sort Winton, D. J.
collection PubMed
description We show that, from the earliest morphologically recognisable stages of development, mouse skin papillomas induced by a chemical initiation-promotion regime are polyclonal. We have demonstrated polyclonality directly by immunohistochemical staining of the mosaic cell populations in embryo aggregation chimaeras, a method which removes some of the uncertainties of previous conclusions based on analysis using electrophoretic polymorphisms. The findings may imply that initiation within a single cell and promotion of its clonal descendents is not a sufficient explanation for the origin of these tumours and that interaction between cells of more than one clone is involved. IMAGES:
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spelling pubmed-22473332009-09-10 Polyclonal origin of mouse skin papillomas. Winton, D. J. Blount, M. A. Ponder, B. A. Br J Cancer Research Article We show that, from the earliest morphologically recognisable stages of development, mouse skin papillomas induced by a chemical initiation-promotion regime are polyclonal. We have demonstrated polyclonality directly by immunohistochemical staining of the mosaic cell populations in embryo aggregation chimaeras, a method which removes some of the uncertainties of previous conclusions based on analysis using electrophoretic polymorphisms. The findings may imply that initiation within a single cell and promotion of its clonal descendents is not a sufficient explanation for the origin of these tumours and that interaction between cells of more than one clone is involved. IMAGES: Nature Publishing Group 1989-07 /pmc/articles/PMC2247333/ /pubmed/2803917 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Winton, D. J.
Blount, M. A.
Ponder, B. A.
Polyclonal origin of mouse skin papillomas.
title Polyclonal origin of mouse skin papillomas.
title_full Polyclonal origin of mouse skin papillomas.
title_fullStr Polyclonal origin of mouse skin papillomas.
title_full_unstemmed Polyclonal origin of mouse skin papillomas.
title_short Polyclonal origin of mouse skin papillomas.
title_sort polyclonal origin of mouse skin papillomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247333/
https://www.ncbi.nlm.nih.gov/pubmed/2803917
work_keys_str_mv AT wintondj polyclonaloriginofmouseskinpapillomas
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