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Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.

The presence of specific and high affinity epidermal growth factor receptors (EGF-R) has been demonstrated in human prostate cancer (CaP). Scatchard analysis of the binding data revealed a linear plot consistent with a single class of binding sites with a mean dissociation constant (Kd) +/- s.d. = 1...

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Autores principales: Maddy, S. Q., Chisholm, G. D., Busuttil, A., Habib, F. K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247342/
https://www.ncbi.nlm.nih.gov/pubmed/2478180
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author Maddy, S. Q.
Chisholm, G. D.
Busuttil, A.
Habib, F. K.
author_facet Maddy, S. Q.
Chisholm, G. D.
Busuttil, A.
Habib, F. K.
author_sort Maddy, S. Q.
collection PubMed
description The presence of specific and high affinity epidermal growth factor receptors (EGF-R) has been demonstrated in human prostate cancer (CaP). Scatchard analysis of the binding data revealed a linear plot consistent with a single class of binding sites with a mean dissociation constant (Kd) +/- s.d. = 1.6 +/- 0.4 nmol 1-1. Additionally the binding was specific for EGF since no other competitor than EGF was able to displace the binding of the labelled ligand from its receptor. Comparison of the concentrations of EGF-R in tissues from 19 patients with CaP with those measured in a group of 18 patients with benign prostatic hyperplasia (BPH) reveal that the expression of EGF-R was significantly higher in BPH (mean +/- s.d. = 125 +/- 7 fmol mg protein-1) than in CaP (52 +/- 11 fmol mg protein-1; P less than 0.01). Furthermore, in CaP the expression of EGF-R varied according to the histological grade of the cancer: well differentiated tumours demonstrated more receptors (84 +/- 13 fmol mg protein-1) than poorly differentiated tumours (22 +/- 5 fmol mg protein-1; P less than 0.01). Clearly the depletion in the expression of EGF receptors in CaP is a function of the histological grade of the cancer and as such EGF receptors could be used as a biochemical marker for tumour differentiation.
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spelling pubmed-22473422009-09-10 Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour. Maddy, S. Q. Chisholm, G. D. Busuttil, A. Habib, F. K. Br J Cancer Research Article The presence of specific and high affinity epidermal growth factor receptors (EGF-R) has been demonstrated in human prostate cancer (CaP). Scatchard analysis of the binding data revealed a linear plot consistent with a single class of binding sites with a mean dissociation constant (Kd) +/- s.d. = 1.6 +/- 0.4 nmol 1-1. Additionally the binding was specific for EGF since no other competitor than EGF was able to displace the binding of the labelled ligand from its receptor. Comparison of the concentrations of EGF-R in tissues from 19 patients with CaP with those measured in a group of 18 patients with benign prostatic hyperplasia (BPH) reveal that the expression of EGF-R was significantly higher in BPH (mean +/- s.d. = 125 +/- 7 fmol mg protein-1) than in CaP (52 +/- 11 fmol mg protein-1; P less than 0.01). Furthermore, in CaP the expression of EGF-R varied according to the histological grade of the cancer: well differentiated tumours demonstrated more receptors (84 +/- 13 fmol mg protein-1) than poorly differentiated tumours (22 +/- 5 fmol mg protein-1; P less than 0.01). Clearly the depletion in the expression of EGF receptors in CaP is a function of the histological grade of the cancer and as such EGF receptors could be used as a biochemical marker for tumour differentiation. Nature Publishing Group 1989-07 /pmc/articles/PMC2247342/ /pubmed/2478180 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Maddy, S. Q.
Chisholm, G. D.
Busuttil, A.
Habib, F. K.
Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.
title Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.
title_full Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.
title_fullStr Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.
title_full_unstemmed Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.
title_short Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.
title_sort epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247342/
https://www.ncbi.nlm.nih.gov/pubmed/2478180
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