Pattern of expression of c-erbB-2 oncoprotein in human fetuses.

The pattern of expression of the c-erbB-2 oncoprotein was investigated in whole mount preparations of 11 human fetuses by immunocytochemistry using two polyclonal antibodies, 20N and 21N. c-erbB-2 was widely expressed within all three germ layers. Expression remained relatively constant in epithelia...

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Autores principales: Quirke, P., Pickles, A., Tuzi, N. L., Mohamdee, O., Gullick, W. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247351/
https://www.ncbi.nlm.nih.gov/pubmed/2572267
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author Quirke, P.
Pickles, A.
Tuzi, N. L.
Mohamdee, O.
Gullick, W. J.
author_facet Quirke, P.
Pickles, A.
Tuzi, N. L.
Mohamdee, O.
Gullick, W. J.
author_sort Quirke, P.
collection PubMed
description The pattern of expression of the c-erbB-2 oncoprotein was investigated in whole mount preparations of 11 human fetuses by immunocytochemistry using two polyclonal antibodies, 20N and 21N. c-erbB-2 was widely expressed within all three germ layers. Expression remained relatively constant in epithelial, mesodermal and extraembryonic tissues, but varied over time during the development of the fetal skeleton. Western blotting failed to detect c-erbB-2 in normal fetal tissues but did confirm expression in a microvillous membrane preparation of placenta. c-erbB-2 expression is widespread in the human fetus and occurs at an earlier stage than epidermal growth factor receptor. IMAGES:
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spelling pubmed-22473512009-09-10 Pattern of expression of c-erbB-2 oncoprotein in human fetuses. Quirke, P. Pickles, A. Tuzi, N. L. Mohamdee, O. Gullick, W. J. Br J Cancer Research Article The pattern of expression of the c-erbB-2 oncoprotein was investigated in whole mount preparations of 11 human fetuses by immunocytochemistry using two polyclonal antibodies, 20N and 21N. c-erbB-2 was widely expressed within all three germ layers. Expression remained relatively constant in epithelial, mesodermal and extraembryonic tissues, but varied over time during the development of the fetal skeleton. Western blotting failed to detect c-erbB-2 in normal fetal tissues but did confirm expression in a microvillous membrane preparation of placenta. c-erbB-2 expression is widespread in the human fetus and occurs at an earlier stage than epidermal growth factor receptor. IMAGES: Nature Publishing Group 1989-07 /pmc/articles/PMC2247351/ /pubmed/2572267 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Quirke, P.
Pickles, A.
Tuzi, N. L.
Mohamdee, O.
Gullick, W. J.
Pattern of expression of c-erbB-2 oncoprotein in human fetuses.
title Pattern of expression of c-erbB-2 oncoprotein in human fetuses.
title_full Pattern of expression of c-erbB-2 oncoprotein in human fetuses.
title_fullStr Pattern of expression of c-erbB-2 oncoprotein in human fetuses.
title_full_unstemmed Pattern of expression of c-erbB-2 oncoprotein in human fetuses.
title_short Pattern of expression of c-erbB-2 oncoprotein in human fetuses.
title_sort pattern of expression of c-erbb-2 oncoprotein in human fetuses.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247351/
https://www.ncbi.nlm.nih.gov/pubmed/2572267
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