Cargando…

Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one

New lanthanide(III) complexes with 2-[2-hydroxy-3-methoxyphenyl]-3-[hydroxyl-3-methoxybenzylamino]-1,2-dihydroquin- azoline-4(3H)-one (Hmpbaq) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibilities, spectroscopic (IR, NMR, UV, EPR), and the...

Descripción completa

Detalles Bibliográficos
Autores principales: Gudasi, Kalagouda B., Havanur, Vidyadhar C., Patil, Siddappa A., Patil, Basavaraj R.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248225/
https://www.ncbi.nlm.nih.gov/pubmed/18309372
http://dx.doi.org/10.1155/2007/37348
_version_ 1782150983243005952
author Gudasi, Kalagouda B.
Havanur, Vidyadhar C.
Patil, Siddappa A.
Patil, Basavaraj R.
author_facet Gudasi, Kalagouda B.
Havanur, Vidyadhar C.
Patil, Siddappa A.
Patil, Basavaraj R.
author_sort Gudasi, Kalagouda B.
collection PubMed
description New lanthanide(III) complexes with 2-[2-hydroxy-3-methoxyphenyl]-3-[hydroxyl-3-methoxybenzylamino]-1,2-dihydroquin- azoline-4(3H)-one (Hmpbaq) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibilities, spectroscopic (IR, NMR, UV, EPR), and thermal studies. Molar conductance studies indicate 1 : 1 electrolytic behavior for these complexes. IR spectra indicate that Hmpbaq acts as a tridentate ligand coordinating through carbonyl oxygen, benzyl amine nitrogen, and deprotonated phenolic oxygen. TG and DTA studies of La(III) and Pr(III) complexes indicate the presence of two coordinated water molecules. Based on these studies, the complexes have been formulated as [La(mpbaq)(2)(H(2)O)(2)] [Formula: see text] NO(3), where Ln = La(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Th(III), Dy(III), and Y(III). The ligand, lanthanide(III) salts, and the corresponding complexes have been simultaneously screened for their antibacterial and antifungal activities and compared with the drugs in use.
format Text
id pubmed-2248225
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-22482252008-02-28 Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one Gudasi, Kalagouda B. Havanur, Vidyadhar C. Patil, Siddappa A. Patil, Basavaraj R. Met Based Drugs Research Article New lanthanide(III) complexes with 2-[2-hydroxy-3-methoxyphenyl]-3-[hydroxyl-3-methoxybenzylamino]-1,2-dihydroquin- azoline-4(3H)-one (Hmpbaq) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibilities, spectroscopic (IR, NMR, UV, EPR), and thermal studies. Molar conductance studies indicate 1 : 1 electrolytic behavior for these complexes. IR spectra indicate that Hmpbaq acts as a tridentate ligand coordinating through carbonyl oxygen, benzyl amine nitrogen, and deprotonated phenolic oxygen. TG and DTA studies of La(III) and Pr(III) complexes indicate the presence of two coordinated water molecules. Based on these studies, the complexes have been formulated as [La(mpbaq)(2)(H(2)O)(2)] [Formula: see text] NO(3), where Ln = La(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Th(III), Dy(III), and Y(III). The ligand, lanthanide(III) salts, and the corresponding complexes have been simultaneously screened for their antibacterial and antifungal activities and compared with the drugs in use. Hindawi Publishing Corporation 2007 2008-02-13 /pmc/articles/PMC2248225/ /pubmed/18309372 http://dx.doi.org/10.1155/2007/37348 Text en Copyright © 2007 Kalagouda B. Gudasi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gudasi, Kalagouda B.
Havanur, Vidyadhar C.
Patil, Siddappa A.
Patil, Basavaraj R.
Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one
title Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one
title_full Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one
title_fullStr Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one
title_full_unstemmed Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one
title_short Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one
title_sort antimicrobial study of newly synthesized lanthanide(iii) complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3h)-one
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248225/
https://www.ncbi.nlm.nih.gov/pubmed/18309372
http://dx.doi.org/10.1155/2007/37348
work_keys_str_mv AT gudasikalagoudab antimicrobialstudyofnewlysynthesizedlanthanideiiicomplexesof22hydroxy3methoxyphenyl32hydroxy3methoxybenzylamino12dihydroquinazolin43hone
AT havanurvidyadharc antimicrobialstudyofnewlysynthesizedlanthanideiiicomplexesof22hydroxy3methoxyphenyl32hydroxy3methoxybenzylamino12dihydroquinazolin43hone
AT patilsiddappaa antimicrobialstudyofnewlysynthesizedlanthanideiiicomplexesof22hydroxy3methoxyphenyl32hydroxy3methoxybenzylamino12dihydroquinazolin43hone
AT patilbasavarajr antimicrobialstudyofnewlysynthesizedlanthanideiiicomplexesof22hydroxy3methoxyphenyl32hydroxy3methoxybenzylamino12dihydroquinazolin43hone