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Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one
New lanthanide(III) complexes with 2-[2-hydroxy-3-methoxyphenyl]-3-[hydroxyl-3-methoxybenzylamino]-1,2-dihydroquin- azoline-4(3H)-one (Hmpbaq) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibilities, spectroscopic (IR, NMR, UV, EPR), and the...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248225/ https://www.ncbi.nlm.nih.gov/pubmed/18309372 http://dx.doi.org/10.1155/2007/37348 |
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author | Gudasi, Kalagouda B. Havanur, Vidyadhar C. Patil, Siddappa A. Patil, Basavaraj R. |
author_facet | Gudasi, Kalagouda B. Havanur, Vidyadhar C. Patil, Siddappa A. Patil, Basavaraj R. |
author_sort | Gudasi, Kalagouda B. |
collection | PubMed |
description | New lanthanide(III) complexes with 2-[2-hydroxy-3-methoxyphenyl]-3-[hydroxyl-3-methoxybenzylamino]-1,2-dihydroquin- azoline-4(3H)-one (Hmpbaq) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibilities, spectroscopic (IR, NMR, UV, EPR), and thermal studies. Molar conductance studies indicate 1 : 1 electrolytic behavior for these complexes. IR spectra indicate that Hmpbaq acts as a tridentate ligand coordinating through carbonyl oxygen, benzyl amine nitrogen, and deprotonated phenolic oxygen. TG and DTA studies of La(III) and Pr(III) complexes indicate the presence of two coordinated water molecules. Based on these studies, the complexes have been formulated as [La(mpbaq)(2)(H(2)O)(2)] [Formula: see text] NO(3), where Ln = La(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Th(III), Dy(III), and Y(III). The ligand, lanthanide(III) salts, and the corresponding complexes have been simultaneously screened for their antibacterial and antifungal activities and compared with the drugs in use. |
format | Text |
id | pubmed-2248225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-22482252008-02-28 Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one Gudasi, Kalagouda B. Havanur, Vidyadhar C. Patil, Siddappa A. Patil, Basavaraj R. Met Based Drugs Research Article New lanthanide(III) complexes with 2-[2-hydroxy-3-methoxyphenyl]-3-[hydroxyl-3-methoxybenzylamino]-1,2-dihydroquin- azoline-4(3H)-one (Hmpbaq) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibilities, spectroscopic (IR, NMR, UV, EPR), and thermal studies. Molar conductance studies indicate 1 : 1 electrolytic behavior for these complexes. IR spectra indicate that Hmpbaq acts as a tridentate ligand coordinating through carbonyl oxygen, benzyl amine nitrogen, and deprotonated phenolic oxygen. TG and DTA studies of La(III) and Pr(III) complexes indicate the presence of two coordinated water molecules. Based on these studies, the complexes have been formulated as [La(mpbaq)(2)(H(2)O)(2)] [Formula: see text] NO(3), where Ln = La(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Th(III), Dy(III), and Y(III). The ligand, lanthanide(III) salts, and the corresponding complexes have been simultaneously screened for their antibacterial and antifungal activities and compared with the drugs in use. Hindawi Publishing Corporation 2007 2008-02-13 /pmc/articles/PMC2248225/ /pubmed/18309372 http://dx.doi.org/10.1155/2007/37348 Text en Copyright © 2007 Kalagouda B. Gudasi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gudasi, Kalagouda B. Havanur, Vidyadhar C. Patil, Siddappa A. Patil, Basavaraj R. Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one |
title | Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one |
title_full | Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one |
title_fullStr | Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one |
title_full_unstemmed | Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one |
title_short | Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one |
title_sort | antimicrobial study of newly synthesized lanthanide(iii) complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3h)-one |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248225/ https://www.ncbi.nlm.nih.gov/pubmed/18309372 http://dx.doi.org/10.1155/2007/37348 |
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