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Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy

The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF- [Formula: see text] , TGF- [Formula: see text] 1, and MCP-1 in major depression and to investigate the...

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Autores principales: Sutcigil, Levent, Oktenli, Cagatay, Musabak, Ugur, Bozkurt, Ali, Cansever, Adnan, Uzun, Ozcan, Sanisoglu, S. Yavuz, Yesilova, Zeki, Ozmenler, Nahit, Ozsahin, Aytekin, Sengul, Ali
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248234/
https://www.ncbi.nlm.nih.gov/pubmed/18317531
http://dx.doi.org/10.1155/2007/76396
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author Sutcigil, Levent
Oktenli, Cagatay
Musabak, Ugur
Bozkurt, Ali
Cansever, Adnan
Uzun, Ozcan
Sanisoglu, S. Yavuz
Yesilova, Zeki
Ozmenler, Nahit
Ozsahin, Aytekin
Sengul, Ali
author_facet Sutcigil, Levent
Oktenli, Cagatay
Musabak, Ugur
Bozkurt, Ali
Cansever, Adnan
Uzun, Ozcan
Sanisoglu, S. Yavuz
Yesilova, Zeki
Ozmenler, Nahit
Ozsahin, Aytekin
Sengul, Ali
author_sort Sutcigil, Levent
collection PubMed
description The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF- [Formula: see text] , TGF- [Formula: see text] 1, and MCP-1 in major depression and to investigate the effects of sertraline therapy. Cytokine and chemokine levels were measured at the time of admission and 8 weeks after sertraline treatment. Our results suggest that the proinflammatory cytokines (IL-2, IL-12, and TNF- [Formula: see text]) and MCP-1 were significantly higher, whereas anti-inflammatory cytokines IL-4 and TGF- [Formula: see text] 1 were significantly lower in patients with major depression than those of healthy controls. It seems likely that the sertraline therapy might have exerted immunomodulatory effects through a decrease in the proinflammatory cytokine IL-12 and an increase in the anti-inflammatory cytokines IL-4 and TGF- [Formula: see text] 1. In conclusion, our results indicate that Th1-, Th2-, and Th3-type cytokines are altered in the depressed patients and some of them might have been corrected by sertraline treatment.
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spelling pubmed-22482342008-03-03 Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy Sutcigil, Levent Oktenli, Cagatay Musabak, Ugur Bozkurt, Ali Cansever, Adnan Uzun, Ozcan Sanisoglu, S. Yavuz Yesilova, Zeki Ozmenler, Nahit Ozsahin, Aytekin Sengul, Ali Clin Dev Immunol Clinical Study The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF- [Formula: see text] , TGF- [Formula: see text] 1, and MCP-1 in major depression and to investigate the effects of sertraline therapy. Cytokine and chemokine levels were measured at the time of admission and 8 weeks after sertraline treatment. Our results suggest that the proinflammatory cytokines (IL-2, IL-12, and TNF- [Formula: see text]) and MCP-1 were significantly higher, whereas anti-inflammatory cytokines IL-4 and TGF- [Formula: see text] 1 were significantly lower in patients with major depression than those of healthy controls. It seems likely that the sertraline therapy might have exerted immunomodulatory effects through a decrease in the proinflammatory cytokine IL-12 and an increase in the anti-inflammatory cytokines IL-4 and TGF- [Formula: see text] 1. In conclusion, our results indicate that Th1-, Th2-, and Th3-type cytokines are altered in the depressed patients and some of them might have been corrected by sertraline treatment. Hindawi Publishing Corporation 2007 2008-01-20 /pmc/articles/PMC2248234/ /pubmed/18317531 http://dx.doi.org/10.1155/2007/76396 Text en Copyright © 2007 Levent Sutcigil et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Sutcigil, Levent
Oktenli, Cagatay
Musabak, Ugur
Bozkurt, Ali
Cansever, Adnan
Uzun, Ozcan
Sanisoglu, S. Yavuz
Yesilova, Zeki
Ozmenler, Nahit
Ozsahin, Aytekin
Sengul, Ali
Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
title Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
title_full Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
title_fullStr Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
title_full_unstemmed Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
title_short Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
title_sort pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248234/
https://www.ncbi.nlm.nih.gov/pubmed/18317531
http://dx.doi.org/10.1155/2007/76396
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