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Early Expression of Fc [Formula: see text] RI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients

Objective. Activation of innate immunity cells is inseparably linked to cardiac surgical operation. The aim of this study was to assess the kinetics in the expression of receptor for Fc part of IgG, Fc [Formula: see text] RI (CD64), and scavenger receptor CD163 on peripheral blood cells of cardiac s...

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Autores principales: Kolackova, Martina, Kudlova, Manuela, Kunes, Pavel, Lonsky, Vladimir, Mandak, Jiri, Andrys, Ctirad, Jankovicova, Karolina, Krejsek, Jan
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248246/
https://www.ncbi.nlm.nih.gov/pubmed/18320015
http://dx.doi.org/10.1155/2008/235461
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author Kolackova, Martina
Kudlova, Manuela
Kunes, Pavel
Lonsky, Vladimir
Mandak, Jiri
Andrys, Ctirad
Jankovicova, Karolina
Krejsek, Jan
author_facet Kolackova, Martina
Kudlova, Manuela
Kunes, Pavel
Lonsky, Vladimir
Mandak, Jiri
Andrys, Ctirad
Jankovicova, Karolina
Krejsek, Jan
author_sort Kolackova, Martina
collection PubMed
description Objective. Activation of innate immunity cells is inseparably linked to cardiac surgical operation. The aim of this study was to assess the kinetics in the expression of receptor for Fc part of IgG, Fc [Formula: see text] RI (CD64), and scavenger receptor CD163 on peripheral blood cells of cardiac surgical patients and to examine the effect of cardiac bypass as a separable influence on the systemic acute inflammatory response. Methods. Forty patients, twenty in each group, were randomly assigned to CABG surgery performed either with “on-pump” or without “off-pump” cardiopulmonary bypass. Standardized quantitative flow cytometry method was used to determine the expression of surface markers. Results. The density of CD64 molecule on monocytes reached maximum on the 1st postoperative day ([Formula: see text]) whereas the peak for CD64 molecule expression on granulocytes was postponed to the 3rd postoperative day ([Formula: see text]). The expression of CD163 scavenger molecule on monocytes reached maximum on the 1st postoperative day ([Formula: see text]). The density of CD163 molecule on monocytes on the 1st postoperative day is significantly higher in “on-pump” patients in comparison with “off-pump” patients ([Formula: see text]). Conclusion. In cardiac surgical patients the expression of activation marker Fc [Formula: see text] R1 (CD64) on monocytes is increased earlier in comparison with granulocytes in both “on-pump” and “off-pump” patients. The expression of scavenger molecule CD163 on monocytes is significantly higher in “on-pump” patients.
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spelling pubmed-22482462008-03-04 Early Expression of Fc [Formula: see text] RI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients Kolackova, Martina Kudlova, Manuela Kunes, Pavel Lonsky, Vladimir Mandak, Jiri Andrys, Ctirad Jankovicova, Karolina Krejsek, Jan Mediators Inflamm Clinical Study Objective. Activation of innate immunity cells is inseparably linked to cardiac surgical operation. The aim of this study was to assess the kinetics in the expression of receptor for Fc part of IgG, Fc [Formula: see text] RI (CD64), and scavenger receptor CD163 on peripheral blood cells of cardiac surgical patients and to examine the effect of cardiac bypass as a separable influence on the systemic acute inflammatory response. Methods. Forty patients, twenty in each group, were randomly assigned to CABG surgery performed either with “on-pump” or without “off-pump” cardiopulmonary bypass. Standardized quantitative flow cytometry method was used to determine the expression of surface markers. Results. The density of CD64 molecule on monocytes reached maximum on the 1st postoperative day ([Formula: see text]) whereas the peak for CD64 molecule expression on granulocytes was postponed to the 3rd postoperative day ([Formula: see text]). The expression of CD163 scavenger molecule on monocytes reached maximum on the 1st postoperative day ([Formula: see text]). The density of CD163 molecule on monocytes on the 1st postoperative day is significantly higher in “on-pump” patients in comparison with “off-pump” patients ([Formula: see text]). Conclusion. In cardiac surgical patients the expression of activation marker Fc [Formula: see text] R1 (CD64) on monocytes is increased earlier in comparison with granulocytes in both “on-pump” and “off-pump” patients. The expression of scavenger molecule CD163 on monocytes is significantly higher in “on-pump” patients. Hindawi Publishing Corporation 2008 2008-02-19 /pmc/articles/PMC2248246/ /pubmed/18320015 http://dx.doi.org/10.1155/2008/235461 Text en Copyright © 2008 Martina Kolackova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Kolackova, Martina
Kudlova, Manuela
Kunes, Pavel
Lonsky, Vladimir
Mandak, Jiri
Andrys, Ctirad
Jankovicova, Karolina
Krejsek, Jan
Early Expression of Fc [Formula: see text] RI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients
title Early Expression of Fc [Formula: see text] RI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients
title_full Early Expression of Fc [Formula: see text] RI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients
title_fullStr Early Expression of Fc [Formula: see text] RI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients
title_full_unstemmed Early Expression of Fc [Formula: see text] RI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients
title_short Early Expression of Fc [Formula: see text] RI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients
title_sort early expression of fc [formula: see text] ri (cd64) on monocytes of cardiac surgical patients and higher density of monocyte anti-inflammatory scavenger cd163 receptor in “on-pump” patients
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248246/
https://www.ncbi.nlm.nih.gov/pubmed/18320015
http://dx.doi.org/10.1155/2008/235461
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