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Gating Charge Immobilization in Kv4.2 Channels: The Basis of Closed-State Inactivation
Kv4 channels mediate the somatodendritic A-type K(+) current (I(SA)) in neurons. The availability of functional Kv4 channels is dynamically regulated by the membrane potential such that subthreshold depolarizations render Kv4 channels unavailable. The underlying process involves inactivation from cl...
Autores principales: | Dougherty, Kevin, De Santiago-Castillo, Jose A., Covarrubias, Manuel |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248721/ https://www.ncbi.nlm.nih.gov/pubmed/18299396 http://dx.doi.org/10.1085/jgp.200709938 |
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