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The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation

HIV-1 uses a programmed -1 ribosomal frameshift to synthesize the precursor of its enzymes, Gag-Pol. The frameshift efficiency that is critical for the virus replication, is controlled by an interaction between the ribosome and a specific structure on the viral mRNA, the frameshift stimulatory signa...

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Detalles Bibliográficos
Autores principales:	Gendron, Karine, Charbonneau, Johanie, Dulude, Dominic, Heveker, Nikolaus, Ferbeyre, Gerardo, Brakier-Gingras, Léa
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248755/ https://www.ncbi.nlm.nih.gov/pubmed/17984074 http://dx.doi.org/10.1093/nar/gkm906

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