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Protein evolution by hypermutation and selection in the B cell line DT40

Genome-wide mutations and selection within a population are the basis of natural evolution. A similar process occurs during antibody affinity maturation when immunoglobulin genes are hypermutated and only those B cells which express antibodies of improved antigen-binding specificity are expanded. Pr...

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Detalles Bibliográficos
Autores principales:	Arakawa, Hiroshi, Kudo, Hiroaki, Batrak, Vera, Caldwell, Randolph B., Rieger, Michael A., Ellwart, Joachim W., Buerstedde, Jean-Marie
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248763/ https://www.ncbi.nlm.nih.gov/pubmed/18073192 http://dx.doi.org/10.1093/nar/gkm616

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