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Adaptor SKAP-55 Binds p21(ras) Activating Exchange Factor RasGRP1 and Negatively Regulates the p21(ras)-ERK Pathway in T-Cells

While the adaptor SKAP-55 mediates LFA-1 adhesion on T-cells, it is not known whether the adaptor regulates other aspects of signaling. SKAP-55 could potentially act as a node to coordinate the modulation of adhesion with downstream signaling. In this regard, the GTPase p21(ras) and the extracellula...

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Detalles Bibliográficos
Autores principales:	Schneider, Helga, Wang, Hongyan, Raab, Monika, Valk, Elke, Smith, Xin, Lovatt, Matt, Wu, Zhonglin, Maqueira-Iglesias, Braudel, Strebhardt, Klaus, Rudd, Christopher E.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249700/ https://www.ncbi.nlm.nih.gov/pubmed/18320039 http://dx.doi.org/10.1371/journal.pone.0001718

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